Table of contents for Protein-protein interactions as new drug targets / Enno Klussmann, John Scott, editors ; contributors, E.M. Aandahl ... [et al.].


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Part I Organization of Scaffolds
A-Kinase Anchoring Proteins as the Basis for cAMP Signaling ........  3
K.L. Dodge-Kafka, A. Bauman,
and M.S. Kapiloff
Arrestins as Multi-Functional Signaling Adaptors ...................  15
V.V. Gurevich, E.V. Gurevich,
and W.M. Cleghorn
Role of Ena/VASP Proteins in Homeostasisand Disease ...............  39
G. Pula and M. Krause
Scaffold/Matrix Attachment Regions (S/MARs):
Relevance for Disease and Therapy..............................  67
A. Gluch, M. Vidakovic, and J. Bode
Clathrin/AP-2-Dependent Endocytosis:
A Novel Playground for the Pharmacological Toolbox? ............... 105
C. Rodemer and V. Haucke
Part II Scaffolding Proteins and Cellular Signalling
PDE4 Associates with Different Scaffolding
Proteins: Modulating Interactions as Treatment for Certain Diseases ... 125
A.C. McCahill, E. Huston, X. Li,
and M.D. Houslay
G-Protein-Coupled Receptor-Signaling Components in Membrane
Raft and Caveolae Microdomains ..............................  167
H.H. Patel, F. Murray, and P.A. Insel
Protein Scaffolds, Lipid Domains and Substrate
Recognition in Protein Kinase C Function. Implications
for Rational Drug Design ...................................... .. 185
J.W. Walker
Compartmentalised MAPK Pathways ...........................    205
M.D. Brown and D.B. Sacks
Dynamic Protein Complexes Regulate NF-icB Signaling .............. 237
E. Wegener and D. Krappmann
An Oncogenic Hub: p-Catenin as a Molecular Target
for Cancer Therapeutics .................  ..................... 261
K.-I. Takemaru, M. Ohmitsu, and E-Q. Li
A Toolkit for Real-Time Detection of cAMP:
Insights into Compartmentalized Signaling ........................ 285
M. Berrera, G. Dodoni, S. Monterisi,
V. Pertegato, I. Zamparo, and M. Zaccolo
Part III Cell Type-Specific Anchoring
Scaffolding Proteins in Cardiac Myocytes .......................... 301
N.L. Chudasama, S.O. Marx, and S.F Steinberg
Molecular Architecture of Signal Complexes
Regulating Immune Cell Function ............... ................ 327
K.M. Torgersen, E.M. Aandahl, and K. Task6n
Scaffolding Proteins at the Postsynaptic Density:Shank
as the Architectural Framework ................................. 365
H.J. Kreienkamp
Part IV Interference with Protein-Protein Interaction
Sites as a New Pharmacological Concept
Domains Mediate Protein-Protein Interactions
and Nucleate Protein Assemblies. ...............................  383
S. Costa and G. Cesareni
Proline-Rich Sequence Recognition Domains (PRD):
Ligands, Function and Inhibition .............................. 407
C. Freund, H.G. Schmalz, J. Sticht, and R. Kiihne
Chemical Inhibition Through Conformational Stabilization
of Rho GTPase Effectors  ..... ................................  431
S.W. Deacon and J.R. Peterson
Pharmacological Interference with Protein-Protein Interactions
M ediated by Coiled-Coil Motifs  ................................   461
H.M. Strauss and S. Keller
Direct AKAP-Mediated Protein-Protein Interactions
as Potential Drug Targets...... .............................. 483
C. Hundsrucker and E. Klussmann



Library of Congress subject headings for this publication: Drug targeting, Protein-protein interactions