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Part I Cardiovascular Complications and In Vitro Models 1. Heart Disease in AIDS 1 Qianli Yu and Ronald Ross Watson 2. Mechanisms of Atherogenesis in HIV Infection 7 Guha Krishnaswamy, Kai Liu, Chuangfu Li, Daniel Sijipunda Dube, and David S. Chi 3. Role of HIV-1 Macropinocytosis and Cardiomyocyte Apoptosis in the Pathogenesis of HIV Cardiomyopathy 33 Milan Fiala, Kenneth P. Roos, William R. MacLellan, and Albert S. Lossinsky 4. HIV-1 and the Blood-Brain Barrier 41 Kwang Sik Kim 5. HIV, Cocaine, and the Heart: Pathophysiology and Clinical Implications 55 John F. Setaro, Brian G. Abbott, and Arthur Margolin 6. HIV-Associated Thrombotic Microangiopathy 71 Anja S. Miihlfeld, Stephan Segerer, and Charles E. Alpers 7. Pathogenesis of HIV-Associated Vasculopathy 85 Lance S. Terada and Ru Feng Wu 8. Causative Factors of Cardiovascular Complications in AIDS 101 Yinhong Chen and Ronald Ross Watson 9. HIV-Associated Vascular Disease and Endothelial Injury 111 Changyi (Johnny) Chen, Peter H. Lin, Alan B. Lumsden, and Qizhi (Cathy) Yao 10. Tat-Induced Angiogenesis 129 Harris E. McFerrin, Deborah E. Sullivan, Anne B. Nelson, Heather L. LaMarca, Bryan D. Shelby, and Cindy A. Morris Part II Nutrition: Causation and Prevention 11. Nutrients as Modulators of Immune Dysfunction and Dyslipidemia in AIDS 163 Raxit J. Jariwalla 12. Antioxidant Vitamins and Heart Disease Prevention 177 Jin Zhang and Ronald Ross Watson 13. Nutrients and Treatment of Heart Disease in AIDS 187 Ramon Tomds Sepulvedc and Ronald Ross Watson 14. Will Soy Protein Help HIV Patients with Cardiovascular Risk? 197 Kelly J. Blackstock 15. N-3 Fatty Acid Supplementation in AIDS Patients with Cardiac Complications 205 Zeina Makhoul 16. A Role for Dietary Protein in the AIDS Wasting Syndrome and Heart Disease? 217 Jaclyn Maurer 17. Role of Antioxidants in Reducing Heart Disease in HIV-Infected Patients 225 Yingying Liu and Ronald Ross Watson 18. Antioxidant Vitamins and Antiretroviral Therapy During HIV Infection: Effects on Oxidative Damage 233 Jin Zhang and Ronald Ross Watson 19. Vitamin E Retards Heart Disease in AIDS Patients 241 Jennifer J. Ravia and Ronald Ross Watson Part III Drug Abuse: Promotion of Retroviral Heart Disease 20. HIV- and Cocaine-Induced Subclinical Atherosclerosis 247 Shenghan Lai, Qingyi Meng, and Jodo A. C. Lima 21. Cocaine, HIV, and Heart Disease: Research at NIDA and Recommendations for Future Research 259 Jag H. Khalsa and Sander G. Genser 22. Cocaine-Induced Exacerbation of Viral Myocarditis 265 Jufeng Wang and James P. Morgan 23. Role of the Catecholamine-Nitric Oxide System in Cocaine- and HIV-Induced Vascular Inflammation and Its Pharmacological Implications 281 David S. Chi, William L. Stone, Hiren B. Patel, and Guha Krishnaswamy 24. Cardiovascular Complications of HIV/AIDS and Substance Abuse 299 Jag H. Khalsa Part IV Lipodystrophy 25. Lipids, Lipodystrophy, and AIDS 307 Jean Ducobu and M. C. Payen 26. Pathogenesis of HIV-Associated Cardiovascular Complications in the HAART Era 327 Giuseppe Barbaro 27. Lipodystrophy Syndrome and HIV Disease 347 Aurea Westrick-Thompson and Simin Bourchi-Vaghefi 28. The Role of N-3 Fatty Acids in Preventing Coronary Artery Disease and Arrhythmias in AIDS Patients: A Hypothesis 359 Elizabeth H. Sheppard Part V Animal Models of Retrovirus-Related Heart Disease 29. Cardiovascular Involvement in Simian AIDS in Nonhuman Primates 367 George G. Sokos, Angela A. L. Carville, and Richard P. Shannon 30. Cardiac Disease in HIV-1 Tg Animals 377 Paul Jolicoeur, Ping Yue, Zaher Hanna, Marie-Chantal Simard, and Denis G. Kay 31. Murine AIDS and HIV-1 Dementia 387 Mohsen Araghi-Niknam