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Preface xi Acknowledgments xiii PROLOGUE: 19 OCTOBER I962 1 BOOKS AND BIRDS: "GROWING UP" IN CHICAGO 5 "No Money but Lots of Books"- Bird-watching Quiz Kid--Avery and Schrodinger - Learning to Think: College at i5 2 TARGET, THE GENE: BLOOMINGTON AND "PARADISE" 17 "High-Power Minds"- "Fun and Games" with Max - X-ray Survival - "Long Winter of Rain and Darkness"- "Why Not Me?" 3 STUMBLING ON GOLD: TWO SMART ALECKS IN CAMBRIDGE 31 'A Nagging Yet Productive Symbiosis" - Fiasco - Can't Stop Thinking About DNA - Linus's Mistake - 'Just a Beautiful Helix"-- Steeplechase - Base Pairing 4 A BEAUTIFUL MOLECULE: BEING BELIEVED 61 Convincing Themselves - The Hidden Future - Convincing Colleagues -Announcing the Discovery - The First Publicity - Change at Cold Spring Harbor - "For a Moment, the Room Remained Silent" 5 NOW WHAT? THRASHING AROUND 77 "Dear Rosalind"- Romance, a Summer in Cambridge, and the Genetic Code - "Much Travail" in Pasadena - A "Wiskie Twisty"Party in Woods Hole-Jim "Was Very Introverted Then"-- GettingJim to Harvard - Rejection 6 HARVARD: "FEW DARED CALL HIM TO ACCOUNT" 95 'A Laboratory of Special Influence"- Making Enemies - A "Confidential" Style ofLecturing - Goading Young Researchers - Viruses and Cancer -Increasing Fame - Nobel Prize 7 MANIFESTO AND MARRIAGE 115 Defining the Field: Molecular Biology of the Gene - Does the Ribosome Carry the Message? - The "Perfect Couple"- Messenger RNA- Genetic Code- Forward Gear -A Viewfrom the Periphery - Reverse Gear - Liz 8 "FRESH, ARROGANT, CATTY, BRATTY, AND FUNNY" 143 Watson: "I Can't Imagine Francis Being Harmed" - Crick: 'A Violation of Friendship"- Lwoff "May God Protect Us from Such Friends!"- Morrison: "Seeking Room at the Top" - Why All the Fuss? 9 A PASSION FOR BUILDING: COLD SPRING HARBOR 155 Always Edgy - 'A Lab Near Death"- Big Goals - Fixing the Place Up - The Crucial Gift - "DNA Town"- Limits - Management Style - Succession 1O "HIGHER" CELLS: SCIENCE AT COLD SPRING HARBOR 179 The Pressure to Keep in Touch - "The Next Big Hard Problem"- Restriction Enzymes - Retroviruses -Jim Drops In - Lighting Up the "Cytoskeleton"- "Everybody in the World Came Through"- Close Quarters - Price of Fame - "He'll Give You a Project"- 'Jim Was Really Heartbroken"- "We Were His Yeast Guys"- Split Genes - Gazing "Upward at the Brain" 11 "ODD MAN OUT": RECOMBINANT DNA 215 Germ Warfare? "Ridiculous"- Cloning - "War" on Cancer - Robert Pollack Has a Fit - ' lmost Magical" Tools - Letter to Colleagues: Hold Off- Genetic Engineering and the Bomb - Asilomar II: "The Worst Week ofMy Life"- Hysteria After Asilomar - "I Felt We Were in Real Trouble"- The Critical Year: 977 - Wait Until the Sun Burns Out? 12 GENOME: "IT IS So OBVIOUS" 239 Who? -A Startling Idea - Genetic Focus on Disease - Mapping, Radiation, Cancer, Gene Therapy, And Machines - Santa Cruz - Santa Fe - Storm Clouds - Emotion at Cold Spring Harbor - Hammering Out the Deal: Bruce Alberts' Committee - Colliding with David Baltimore - Start-up - Preemptive Strike: "Some Very Real Dilemmas"-A Splash of ingoism - Opponents Try Again: "In Sitting Here Starving" - Recruiting - "I Was Fired"- "Thank You, Sir" EPILOGUE: "I'M AN OPTIMIST" 271 James Dewey Watson: A Brief Chronology 279 Interviews by the Author 285 Notes 289 Index 347 About the Author 365Library of Congress Subject Headings for this publication: Watson, James D, , 1928-Molecular biologists United States Biography, Molecular genetics, Molecular Biology Biography, DNA history