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Contributing Authors ................... ......... .............ix Preface ........................................................xv Basics 1. Is There Such a Thing as Degenerative Disc Disease? ................. 1 Alf Nachemson 2. Morphologic Changes of Endplates in Degenerative Disc Disease ........ 7 Robert J Moore 3. Biochemical Changes in Degenerative Disc Disease ................. 15 Sally Roberts and Bruce Caterson 4. The Physiology of Intervertebral Disc Degeneration ................. 23 Susan R. S. Bibby, Jing Yu, and Jill P G. Urban 5. Degenerative Disc Disease and Occupational Exposure ............... 35 Malcolm H. Pope 6. Disc Degeneration and Segmental Instability ....................... 53 Tommy Hansson 7. Internal Disc Disruption ................. ................... 63 Henry V Crock Diagnosis 8. Imaging of Degenerative Disc Disease ........................... 75 Jean-Louis Dietemann 9. Behavior of the Disc in Upright Magnetic Resonance Imaging ......... 91 Francis W Smith, J Randy Jinkins, and Malcolm H. Pope 10. Lumbar Discography ........................................ 99 Asif Saifuddin Clinical Presentation 11. Disc Degeneration and Low Back Pain ..........................111 Michel Benoist and Philippe Boulu 12. Disc Degeneration in Children and Adolescents .................... 121 Federico Balaguk and Jean Dudler 26. Total Disc Replacement for Low Back Pain of Discogenic Origin ...... 249 H. Michael Mayer, Karsten Wiechert, andAndreas Korge 27. The PDN Prosthetic Disc Nucleus Device: Product Design and Clinical Results ........................................ 257 SineadA. Kavanagh and Charles D. Ray Economic and Ethical Considerations 28. The Evidence Base for Treatment of-not Degenerative Disc Disease-but Back Pain ................................. 263 Alf Nachemson 29. The Need for Central Registration: Spine Tango. A European Spine Registry ................... ............ ...... 273 Christoph P Roeder, Amer I. EL-Kerdi, Dieter Grob, and Max Aebi 30. Assessment of Health-Related Quality of Life ..................... 279 Christian Melot 31. Rationale for the Surgical Treatment of Degenerative Disc Disease from the Cochrane Review ................................... 291 JN. Alastair Gibson and Gordon Waddell 32. Animal Models in the Study of Degenerative Disc Disease ........... 303 Robert J Moore 33. Epidemiology, Outcome, and Costs of Surgery for Lumbar Disc Herniation ...........................................313 Marc G. Du Bois and Peter Donceel 34. Clinical Outcome, Measurements, and Languages: Some Cultural Aspects ........................................... 321 Margareta Nordin Subject Index ................................. . .............. 327Library of Congress Subject Headings for this publication: Intervertebral disk Diseases, Intervertebral Disk pathology, Spinal Diseases, Intervertebral Disk Displacement