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Preface Contributors 1. Feasibility Assessment in Topical and Transdermal Delivery: Mathematical Models and In Vitro Studies Jonathan Hadgraft and Richard H. Guy 2. Evaluating the Transdermal Permeability of Chemicals Brent E. Vecchia and Annette L. Bunge 3. Skin Absorption Databases and Predictive Equations Brent E. Vecchia and Annette L. Bunge 4. Partitioning of Chemicals into Skin: Results and Predictions Brent E. Vecchia and Annette L. Bunge 5. Iontophoresis: Applications in Drug Delivery and Noninvasive Monitoring M. Begofia Delgado-Charro and Richard H. Guy 6. Skin Electroporation for Transdermal and Topical Drug Delivery Veronique Preat and Rita Vanbever 7. Sonophoresis: Ultrasound-Enhanced Transdermal Drug Delivery Victor Meidan 8. Metabolic Approach to Transdermal Drug Delivery Peter M. Elias, Kenneth R. Feingold, Janice Tsai, Carl Thornfeldt, and Gopinathan Menon 9. The Application of Supersaturated Systems to Percutaneous Drug Delivery Mark Pellett, S. Lakshmi Raghavan, Jonathan Hadgraft, and Adrian Davis 10. Minimally Invasive Systems for Transdermal Drug Delivery James A. Down and Noel G. Harvey 11. Transdermal Drug Delivery System Regulatory Issues Vinod P. ShahLibrary of Congress Subject Headings for this publication: Transdermal medication, Skin Physiology, Administration, Cutaneous, Drug Delivery Systems, Permeability, Skin Absorption physiology