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SECTION I: PLANT IMMUNITY Section Editor: Frederick M. Ausubel Introduction Frederick M . A usubel ...................................................................1 1 Pathogen Recognition and Signal Transduction in Plant Immunity Jonathan Cohn and Gregory B. Martin .......................................................... 3 2 Plant Disease Resistance Genes Jeffrey G. Ellis and David A. Jones ...................................................... 27 3 Nonhost Resistance in Plants to Microbial Pathogens Michele C. Heath .............................................................. 47 SECTION II: INVERTEBRATE HOST DEFENSE IMMUNITY Section Editor: Jean-Marc Reichhart Introduction Jean-M arc Reichhart .................................................................59 4 Regulatory Co-options in the Evolution of Deuterostome Immune Systems Ellen V. Rothenberg and Eric H. Davidson .................................................. 61 5 Antimicrobial Peptides in Insect Immunity Philippe Bulet, Maurice Charlet, and Charles Hetru ................................. 89 6 Innate Immunity in the Horseshoe Crab Shun-ichiro Kawabata, Tsukasa Osaki, and Sadaaki Iwanaga ............... 109 7 Pattern Recognition Receptors in Drosophila Mika Rimet, Alan Pearson, Kati Baksa, and Asha Harikrishnan ........... 127 8 Humoral and Cellular Responses in Drosophila Innate Immunity Julien Royet, Marie Meister, and Dominique Ferrandon ....................... 137 9 Thioester-Containing Proteins of Protostomes Elena A. Levashina, Stephanie Blandin, Luis F. Moita, Marie Lagueux, and Fotis C. Kafatos .....................................................155 SECTION III: MAMMALIAN HOST DEFENSES: PATTERN RECOGNITION RECEPTORS Section Editor: Siamon Gordon Introduction Siamon Gordon ...................................................................... 175 10 Toll-Like Receptors Tsuneyasu Kaisho and Shizuo Akira ..........................................................177 11 The Macrophage Mannose Receptor and Innate Immunity Thiruvamoor P. Ramkumar, Djilali Hammache, and Philip D. Stahl ........................ 191 12 Diverse Roles of Lung Collectins in Pulmonary Innate Immunity Erika C. Crouch and Jeffrey A. Whitsett ...................................................205 13 Structures of Complement Control Proteins Thilo Stehle and Mykol Larvie.......................................................... 231 14 Lipopolysaccharide-Binding Protein and CD14 Peter S. Tobias ..................................................................255 SECTION IV: MAMMALIAN HOST DEFENSES: LINKS BETWEEN INNATE AND ADAPTIVE IMMUNITY Section Editor: Steven L. Kunkel Introduction Steven L. Kunkel ..................................................................267 15 The Role of Chemokines in Linking Innate and Adaptive Immunity Cory M. Hogaboam and Steven L. Kunkel .................................................269 16 Antimicrobial Peptides Tomas Ganz and Robert I. Lehrer .................................................... 287 17 The Role of Complement in Innate and Adaptive Immunity Mihaela Gadjeva, Admar Verschoor, and Michael C. Carroll ............... 305 18 The Role of Natural Killer Cells in Innate Immunity to Infection Wayne M. Yokoyama ............................................................... 321 19 Innate Immune Signaling During Phagocytosis David M. Underhill ............................................................... 341 20 The Role of Mast Cells in Innate Immunity Joshua A. Boyce and K. Frank Austen ......................................................... 361 21 CD1-Restricted T-Cells D. Branch Moody .................................................................. 387 Index........................................ .....................403