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Foreword .........................................7..... Teplice Program I and II - Brief Overview from the Ministry of Environment Karel Bidha .............................................. 9 Some Contributions to an Evaluation of the Teplice Program Bedrich Moldan ......................................... i11 Concluding Remarks Peter W. Preuss ........................................... 13 Closing Comments Josef Syka ..............................................17 Teplice Program: Studies on the Impact of Air Pollution on Human Health (1991-1999) Radim J. Srdm ........................................... 19 Biomarkers of Exposure to Particulate Air Pollution in the Czech Republic Joellen Lewtas, Blanka Binkovd, Iva MiSkovd, Pavel Subrt, Jan Lenteek and Radim J. Srdm . .. 31 Monitoring and Modeling Methods to Support Northern and Southern Bohemia Air Quality Studies: A Historical Perspective Robert K. Stevens, Joseph P. Pinto, Robert D. Willis and Yaacov Mamane ............ 49' Source - Receptor Relations in Teplice and Prachatice Joseph P. Pinto, Robert K. Stevens, Robert D. Willis, Yaacov Mamane, Ziad Ramadan and Philip K. Hopke ........................................71 Air Pollution in Teplice and Prachatice 1992-1999 Ivan Bene.f, Frantifek Sipek, Jan Leni(ek and Ji' Novdk ..................... 81 Fractionation and Chemical Analysis of Urban Air Particulate Extracts Jan Lenitek, Milan Sekyra, Katefina Bedndrkovd, Ivan Benes and Frantisek Sipek ....... 87 Genotoxicity and Embryotoxicity of Organic Compounds Associated with Urban Air Particulate Matter Blanka Binkovd, Drahomir Vesely, Doubravka Veseld, Richard Jelinek and Radim J. Srdm . . . 97. Bacterial Mutagenicity of Fractionated Organic Material Adsorbed on Urban Air Particles Milena Cernd, Dana Pochmanovd, Anna Pastorkovd, Jii Smid and Blanka Binkovd ...... 113 Air Pollution and Pregnancy Outcome Jan Dejmek, Ivo Solanskj, Ivan Benes, Jan Lentiek and Radim J. Srdm ............. 127 Aromatase (CYP19) and 7-Ethoxyresorufin O-Deethylase (CYPlAl) Activities in Human Placental Samples Collected in Two Czech Areas Differing in Pollution Rates Miroslav Machala, JiffNeca, Ludek Bldha, Jan Dejmek and Radim J..Srdm .......... 139 Male Reproductive Health Studies in the Teplice Program: Air Pollution and Semen Quality in Young Czech Men Sally D. Perreault, Sherry G. Selevan, Dagmar Zudovd, Zdena Zudovd, Donald P. Evenson and Jifi Rube .. . . ......... .................... 145 Epidemiologic Aspects of Semen Studies in Teplice and Prachatice, Czech Republic Sherry G. Selevan, Sally D. Perreault and Jill RubeS ................. .... 157 Application of the Sperm Chromatin Structure Assay to the Teplice Program Semen Studies: a New Method for Evaluating Sperm Nuclear Chromatin Damage Donald P. Evenson, Lorna K. Jost, Sally D. Perreault, Sherry G. Selevan and Jih'Rubes ..... 167 Impact of Air Pollution on Sperm Aneuploidy Jil RubeS, MiluSe Vozdovd, Sherry G. Selevan, Wendie A. Robbins and Sally D. Perreault. . . 181 Advances in Understanding Paternally Transmitted Chromosomal Abnormalities Francesco Marchetti, Eddie Sloter and Andrew J. Wyrobek ................... 193 Immunity and Childhood Morbidity in the Teplice Program Irva Hertz-Picciotto, Miroslav Dostal, Rebecca A. James, Jean Keller, Jan Dejmek, Sherry G. Selevan, FrantiSek KoteSovec, Jil Noiieka, Andres Gomez-Caminero, Ganesa Wegienka and Radim J. Srdm ............................... 207 Neurobehavioral Effects of Exposure to Environmental Pollutants in Czech Children David Otto, Ivan Skalik, H. Kenneth Hudnell, Dennis House and Radim J. Srdm ........217 Long Term Trends in Mortality FrantiSek Kotijovec, Jiff Skorkovsky and Jaromir Brynda ................... 243 Daily Mortality and Air Pollution in Northern Bohemia: Different Effects for Men and Women Frantifek Kotieovec, Jil' Skorkovsky, Jaromir Brynda, Annette Peters and Joachim Heinrich . . . 257 Sociological Study - Selected Results Ivan Gabal .............................................269 Hypotheses of the Teplice Program - Risk Assessment Richard Jelinek, Ivan Benef, Milena Cernd, Frantilek Kotegovec, Jan Lenigek Pavel Miiller, Jili Noiieka and Jili Skorkovsky' ......... ......... 289 Publication Activity ...................297 List of Corresponding Authors .............................. 313