Table of contents for HIV and the pathogenesis of AIDS / Jay A. Levy.

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Counter
 CONTENTS 
Preface 
Chapter 1 Discovery, Structure, and Origin of HIV 
I.	Discovery of the AIDS Viruses
II. 	The HIV Virion	
III.	Virus Heterogeneity
IV.	Origin of HIV
Chapter 2 Features of HIV Transmission
I.	HIV in Blood
II.	HIV in Genital Fluids
III.	HIV in Milk, Saliva, and Other Body Fluids
IV.	HIV Transmission by Blood and Blood Products
V. 	Sexual Transmission of HIV
VI.	Maternal-Child Transmission of HIV
Chapter 3 Steps Involved in HIV:Cell Interaction and Virus Entry
I. 	CD4 Receptor
II.	Post-Binding Steps in Virus Entry		
III.	Virus:CD4+Cell Fusion
IV.	Other Potential HIV:Cell Surface Interactions Involved in Virus Entry into CD4+ Cells
V.	Down-modulation of the CD4 Protein
VI.	Infection of Cells Lacking CD4 Expression
VII.	Other Possible HIV-Cell Surface Interactions
VIII.	Other Possible Mechanisms Involved in Virus Entry
IX.	Cell-to-Cell Transfer of HIV 
X. 	Overview of Early Steps in HIV Infection
Chapter 4 Acute HIV Infection and Cells Susceptible to HIV Infection
I.	Acute HIV Infection
II.	Cells and Tissues Infected by HIV
III.	Differences in Cellular Host Range among HIV Isolates 
IV.	Superinfection 
V.	Recombination
Chapter 5 Intracellular Control of HIV Replication 
 
I.	Early Intracellular Events in HIV Infection 
II.	Natural Intracellular Resistance to HIV Replication
III.	Interaction of Cytokines and Viral Proteins with Cellular Factors
IV.	Virus Infection of Quiescent Cells 
IV.	Latency 
Chapter 6 Cytopathic Properties of HIV 
I.	HIV Induction of Cell:Cell Fusion 
II.	Accumulation of Extrachromosomal Viral DNA and Cell Death 
III.	Direct Cellular Toxicity of HIV and Viral Proteins 
IV.	Apoptosis 
V.	Activation
VI.	Role of Superantigens 
Chapter 7 Viral Proteins Determining Biologic Features of HIV
I.	Envelope Region and Cell Tropism 
II.	The Influence of Accessory Proteins on HIV Replication
III.	Envelope Region and Cytopathicity, CD4 Protein Modulation, and sCD4 Neutralization
IV.	Conclusions
Chapter 8 Effect of HIV on Various Tissues and Organ Systems in the Host 
I.	Hematopoietic System
II. Induction of Cytokines and their Effect on Immune Function and HIV Replication
III.	Central Nervous System
IV.	Gastrointestinal System 
V. HIV-associated nephropathy (HIVAN)
VI.	Heart
VII.	Other Organ Systems 
CHAPTER 9 INNATE IMMUNE RESPONSES in HIV INFECTION
I.	Introduction
II.	Characteristics of Innate Immunity
III.	Dendritic Cells
III.	Other Cellular Components of the Innate Immune System
IV.	Soluble Innate Factors
V.	Conclusions
Chapter 10 Humoral Immune Responses to HIV Infection 
	
I.	Detection of AntiHIV Antibodies 
II.	Neutralizing Antibodies 
III.	Enhancing Antibodies 
IV.	AntibodyDependent Cellular Cytotoxicity (ADCC) and AntibodyDependent V.	ComplementFixing Antiviral Antibodies
VI.	Autoimmunity 
Chapter 11	T Lymphocyte Immune Responses in HIV Infection
I.	Introduction 
II.	Cytotoxic T Lymphocytes
III.	Diffuse Infiltrative Lymphocytosis Syndrome 
IV.	CD8+ Cell Noncytotoxic Anti-HIV Activity
IV.	T Regulatory Cells
Chapter 12 HIV Infection and Development of Cancer 
I.	Introduction 
II.	Kaposi's sarcoma 
III.	BCell Lymphomas 
IV.	Anal Carcinoma 
V.	Cervical Carcinoma 
VI.	Summary 
Chapter 13	Overall Features of HIV Pathogenesis: Prognosis for LongTerm Survival 
I.	Cofactors in HIV Infection and Disease Progression 
II.	Features of HIV Pathogenesis 
III.	Prognosis 
IV.	Differences in Clinical Outcome 
V.	Factors Involved In Long-term Survival
VI.	Differences in Clinical Course in SIV Infection
VII.	HighRisk HIV-Exposed Seronegative Individuals
VIII.	Diversity of Viruses Involved in Transmission and Infection
IX.	Relation of HIV Heterogeneity to Pathogenesis in Specific Tissues
X.	Conclusions: Viral and Immunologic Features of HIV Pathogenesis 
Chapter 14 Antiviral Therapies
I.	Introduction
II.	Anti-HIV Therapies
III.	Drug Resistance
IV.	Cellular reservoirs of HIV during Antiviral Therapy
V.	Drug Toxicities
VI. 	Effects of Antiretroviral Therapy on the Immune System
VII.	Immune system-based therapies
VIII.	Immune-System Restoration
IX.	Post-Infection Immunization
X.	Passive Immunotherapy and Use of Antibody-Based Approaches
XI.	Structured Treatment Interruption (STI)
XII. Summary
Chapter 15 Vaccine Development 
I.	Introduction
II.	Background 
III.	Ideal Properties of an Effective Vaccine 
IV.	Inactivated and Attenuated Viruses 
V.	Vaccines Using Purified Envelope gp120 Alone or in Association with an Expression Vector	
VI.	Viral Cores as Vaccines
VII.	Viral DNA Inoculation
VIII.	Other Strategies
IX.	Induction of Mucosal Immunity
X.	Adjuvants
XI.	Potential Problems Involved in Vaccination
XII.	Human Vaccine Trials 
XIII.	Other AntiHIV Prevention Approaches 
XIV.	Summary and Conclusions
Conclusions
Appendix I: 	1993 Revised Classification System for HIV Infection and Expanded AIDS Surveillance Case Definition for Adolescents and Adults
Appendix II:	Clinical Categories
Appendix III:	Conditions Included in the 1993 AIDS Surveillance Case Definition
Appendix IV:	Other Definitions in HIV Infection: CD4+ T-Lymphocyte Categories
References
Index

Library of Congress Subject Headings for this publication:

HIV (Viruses).
HIV infections -- Pathogenesis.
HIV Infections -- etiology.
HIV Infections -- physiopathology.
Acquired Immunodeficiency Syndrome -- etiology.
Acquired Immunodeficiency Syndrome -- physiopathology.
HIV.