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CONTENTS Foreword Preface Acknowledgments Contributors SECTION I FUNDAMENTAL PRINCIPLES OF PHARMACOLOGY..... 1 Drug-Receptor Interactions 2 Pharmacodynamics 3 Pharmacokinetics 4 Drug Metabolism 5 Drug Toxicity SECTION II PRINCIPLES OF NEUROPHARMACOLOGY..... Section IIA Fundamental Principles of Neuropharmacology 6 Principles of Cellular Excitability and Electrochemical Transmission 7 Principles of Nervous System Physiology and Pharmacology Section IIB Principles of Autonomic and Peripheral Nervous System Pharmacology 8 Cholinergic Pharmacology 9 Adrenergic Pharmacology 10 Local Anesthetic Pharmacology Section IIC Principles of Central Nervous System ¼Pharmacology 11 Pharmacology of GABAergic and Glutamatergic Neurotransmission 12 Pharmacology of Dopaminergic Neurotransmission 13 Pharmacology of Serotonergic and Central Adrenergic Neurotransmission 14 Pharmacology of Abnormal Electrical Neurotransmission in the Central Nervous System 15 General Anesthetic Pharmacology 16 Pharmacology of Analgesia 17 Pharmacology of Drug Dependence and ¼Addiction SECTION III PRINCIPLES OF CARDIOVASCULAR PHARMACOLOGY..... 18 Pharmacology of Cardiac Rhythm 19 Pharmacology of Cardiac Contractility 20 Pharmacology of Volume Regulation 21 Pharmacology of Vascular Tone 22 Pharmacology of Hemostasis and Thrombosis 23 Pharmacology of Cholesterol and Lipoprotein Metabolism 24 Integrative Cardiovascular Pharmacology: ¼Hypertension, Ischemic Heart Disease, and Heart Failure SECTION IV PRINCIPLES OF ENDOCRINE PHARMACOLOGY..... 25 Pharmacology of the Hypothalamus and ¼Pituitary Gland 26 Pharmacology of the Thyroid Gland 27 Pharmacology of the Adrenal Cortex 28 Pharmacology of Reproduction 29 Pharmacology of the Endocrine Pancreas 30 Pharmacology of Bone Mineral Homeostasis SECTION V PRINCIPLES OF CHEMOTHERAPY..... 31 Principles of Antimicrobial and Antineoplastic Pharmacology 32 Pharmacology of Bacterial Infections: DNA Replication, Transcription, and Translation 33 Pharmacology of Bacterial Infections: Cell Wall Synthesis 34 Pharmacology of Fungal Infections 35 Pharmacology of Parasitic Infections 36 Pharmacology of Viral Infections 37 Pharmacology of Cancer: Genome Synthesis, Stability, and Maintenance 38 Pharmacology of Cancer: Signal Transduction 39 Principles of Combination Chemotherapy SECTION VI PRINCIPLES OF INFLAMMATION AND IMMUNE PHARMACOLOGY..... 40 Principles of Inflammation and the Immune System 41 Pharmacology of Eicosanoids 42 Histamine Pharmacology 43 Pharmacology of Hematopoiesis and Immunomodulation 44 Pharmacology of Immunosuppression 45 Integrative Inflammation Pharmacology: Peptic Ulcer Disease 46 Integrative Inflammation Pharmacology: Asthma 47 Integrative Inflammation Pharmacology: Gout SECTION VII FUNDAMENTALS OF DRUG DEVELOPMENT AND REGULATION..... 48 Drug Discovery and Preclinical Development 49 Clinical Drug Evaluation and Regulatory Approval 50 Systematic Detection of Adverse Events in Marketed Drugs SECTION VIII POISONING BY DRUGS AND ENVIRONMENTAL TOXINS 51 Poisoning by Drugs and Environmental Toxins SECTION IX FRONTIERS IN PHARMACOLOGY 52 Pharmacogenomics 53 Protein-Based Therapies 54 Drug Delivery Modalities Credit List Index
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