Table of contents for Introduction to genetic principles / David Hyde.

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Brief Contents
1	Introduction
Part One PATTERNS AND MECHANISMS OF CLASSICAL INHERITANCE
2	Mendelian Genetics
3	Mitosis and Meiosis
4	Sex Determination and Linkage (updated since last toc)
5	Modifications to Mendelian Patterns of Inheritance
6	Linkage and Mapping in Eukaryotes
Part Two MOLECULAR BASIS OF INHERITANCE AND GENE EXPRESSION
7	DNA Structure and Chromosome Organization
8	Changes in Chromosome Structure and Number
9	DNA Replication
10	Gene Expression: Transcription
11	Gene Expression: Translation
Part Three DNA TECHNOLOGIES
12	Recombinant DNA Technology
13	Molecular Genetic Manipulation
14	Genomics and Bioinformatics
Part Four CONTROL OF GENE EXPRESSION
15	Prokaryotic Genetics
16	Gene Regulation
17	Mutations and Repair Mechanisms
18	Transposable Elements
19	Extranuclear Inheritance
Part Five GENETICS AND BIOLOGICAL PROCESSES
21	 Developmental Genetics
22		Cancer Genetics
Part Six POPULATION GENETICS AND EVOLUTION
23	 Population Genetics
24		Quantitative Genetics
25		Evolutionary Genetics
Detailed Table of Contents
Preface
About the Author
1	Genetics and the Scientific Method
	1.1	A Brief Overview of the Modern History of Genetics
	1.2	The General Areas of Genetics
	1.3	Why Fruit Flies and Colon Bacteria?
	1.4	Applications of Genetics to the Human Population
		Genetic Linkages
		BOX 1.1 Lysenko, Government, and Failed Genetics
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
part one
Patterns and Mechanisms of Classical Inheritance
2	Mendel's Principles
	2.1	Mendel's Experiments
	2.2	Segregation
	2.3	Independent Assortment
	2.4	Genetic Symbol Conventions
	2.5	Probability
	2.6	Statistics
		Genetic Linkages
		BOX 2.1 Calculating Probabilities from Complex Genotypes
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
3	Mitosis and Meiosis
	3.1	Perspective
	3.2	Cell Structure and Function
	3.3	Chromosomes
	3.4	The Cell Cycle and Its Control Mechanisms
	3.5	Mitosis
	3.6	Meiosis
	3.7	Meiosis in Mammals
	3.8	Life Cycles
	3.9	Comparison Between Mitosis and Meiosis
	3.10	The Chromosomal Theory of Inheritance
		Genetic Linkages
		BOX 3.1 The Relationship Between Meiosis and Mendel's Laws
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
4	Sex Determination and Linkage
	4.1	Sex Determination
	4.2	Proof of the Chromosomal Theory of Inheritance
	4.3	Gene Balance
	4.4	Sex Linkage
	4.5	Pedigree Analysis
		Genetic Linkages
		BOX 4.1 Calculating Genotypic Probabilities from Pedigrees
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
5	Modifications to Mendelian Patterns of Inheritance
	5.1	Variance on Dominance
	5.2	Multiple Alleles
	5.3	Testing Allelism
	5.4	Lethal Alleles
	5.5	Penetrance and Expressivity
	5.6	Genotypic Interactions
	5.7	Epigenetics
		Genetic Linkages
		BOX 5.1 Using Reduced Penetrance Data in a Pedigree
BOX 5.2 Deducing Single-Gene Versus Two-Gene Inheritance 
Mechanisms Based on Phenotypic Ratios
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
6	Linkage and Mapping in Eukaryotes
	6.1	Linkage, Crossing Over, and Recombination: An Overview
	6.2	Diploid Mapping
	6.3	Mapping DNA Sequences
	6.4	Haploid Mapping (Tetrad) Analysis
	6.5	The Mechanism of Recombination
	6.6	Unusual Recombination Events
	6.7	Human Chromosomal Maps
		Genetic Linkages
BOX 6.1 Generating a Recombination Map from Three-Point 
Testcross Data
BOX 6.2 Calculating a Recombination Frequencies from a Linkage 
Map
BOX 6.3 Using Linked DNA Markers to Calculate Genotypic 
Probabilities
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
part two
Molecular Basis of Inheritance and Gene Expression
7	DNA Structure and Chromosome Organization
	7.1	Required Properties of a Genetic Material
	7.2	Evidence of DNA as the Genetic Material
	7.3	Chemistry of Nucleic Acids
	7.4	The Eukaryotic Cell
	7.5	The Eukaryotic Chromosome
		Genetic Linkages
		BOX 7.1 Analysis of the Genetic Material in Prions
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
8	Changes in Chromosome Structure and Number
	8.1	Variation in Chromosome Structure: An Overview
	8.2	Deletions
	8.3	Inversions
	8.4	Translocations
	8.5	Centromeric Breaks
	8.6	Duplications
	8.7	Variation in Chromosome Number: An Overview
	8.8	Aneuploidy
	8.9	Changes in Euploidy
		Genetic Linkages
		BOX 8.1 Deletion Mapping of Recessive Alleles
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
9	DNA Replication
	9.1	The Mechanism of DNA Synthesis
	9.2	The Process of Strand Synthesis
	9.3	The Point of Origin of DNA Replication
	9.4	Termination of Replication
	9.5	Other Replication Structures
	9.6	Eukaryotic DNA replication
		Genetic Linkages
BOX 9.1 The Application of Reasoning to Solve the Structure of 
DNA
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
10	Gene Expression: Transcription
	10.1	Types of RNA
	10.2	Prokaryotic Transcription: Preliminaries
	10.3	Prokaryotic Transcription: The Process
	10.4	Ribosomes and Ribosomal RNA
	10.5	Transfer RNA
	10.6	Eukaryotic Transcription
	10.7	Posttranscriptional Modifications in Eukaryotes
	10.8	MicroRNA
	10.9	Update: The Flow of Genetic Information
		Genetic Linkages
BOX 10.1 Determining Which Eukaryotic RNA Polymerase 
Transcribes a Gene
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
11	Gene Expression: Translation
	11.1	The One-Gene/One-Enzyme Hypothesis
	11.2	Protein Structure
	11.3	The Colinearity of mRNA and Protein Sequences
	11.4	Translation: Preliminaries
	11.5	Translation: The Process
	11.6	Posttranslational Changes to Peptide Chains
	11.7	The Genetic Code
		Genetic Linkages
		BOX 11.1 Reverse Translation from Amino Acid Sequence to 
Deduced Nucleotide Sequence
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
part three
DNA Technologies
12	 Recombinant DNA Technology
	12.1	Cloning DNA
	12.2	DNA Libraries
	12.3	Identifying and Isolating Specific Sequences
	12.4	Restriction Mapping
	12.5	DNA Sequencing
		Genetic Linkages
		BOX 12.1 Determining a Restriction Map
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
13	Application of Recombinant DNA Technology
	13.1	Mapping Mutations in Eukaryotes
	13.2	Cloning Eukaryotic Genes
	13.3	Eukaryotic Vectors
	13.4	Sire-Specific Mutagenesis
	13.5 Introducing Foreign DNA into Cells
	13.6	Mouse Genetics
	13.7	Human Gene Therapy
	13.8	Cloned Organisms
	13.9	Practical Benefits from Gene Cloning
	13.10	Ethical Considerations
		Genetic Linkages
		BOX 13.1 Performing a Genomic Walk
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
14	Genomics and Bioinformatics
	14.1	Approaches to Sequencing a Genome
	14.2	Correlating Various Maps
	14.3	Annotating the Genomic Sequence
	14.4	Transcriptomics
	14.5	Proteomics
	14.6	Ethical Considerations
		Genetic Linkages
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
part four
Control of Gene Expression
15	Genetics of Bacteria and Bacteriophages
	15.1	Bacteria and Bacteriophages in Genetic Research
	15.2	Morphological Characteristics
	15.3	Techniques of Cultivation
	15.4	Bacterial Phenotypes
	15.5	Bacteriophage Life Cycles and Phenotypes
	15.6	Overview of Sexual Processes in Bacteria
	15.7	Transformation
	15.8	Conjugation
	15.9	Transduction
	15.10	Phage Genetics
		Genetic Linkages
BOX 15.1 Distinguishing Between Mapping Through Conjugation 
and Transduction
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
16	Gene Expression: Control in Bacteria and Phages
	16.1	The Operon Model
	16.2	The Lactose Operon (Inducible System)
	16.3	Catabolite Repression
	16.4	The Arabinose Operon
	16.5	The Tryptophan Operon (Repressible System)
	16.6	The Tryptophan Operon (Attenuator-Controlled System)
	16.7	Lytic and Lysogenic Cycles in Phage ?
	16.8	Other Transcriptional Control Systems
	16.9	Translational Control
	16.10	Posttranslational Control
		Genetic Linkages
BOX 16.1 Deducing Expression of lac Structural Genes in Complex 
Merozygotes
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
17	Gene Expression: Control in Eukaryotes
	17.1	The cis Regulatory Elements: Control of RNA Polymerase II Action
	17.2	The trans Regulatory Elements: Proteins
	17.3	The trans Regulatory Elements: RNA
	17.4	Example of a Complex Regulatory Network: The Dorsal Protein
	17.5	The Role of Chromatin in Gene Regulation
	17.6	Methylation of DNA
	17.7	Imprinting
	17.8	Posttranscriptional Regulation
	17.9	Translational Control
	17.10	Posttranslational Control
	17.11	Interaction of Multiple Regulatory Mechanisms
	17.12	Eukaryotic Versus Prokaryotic Gene Regulation
		Genetic Linkages
		BOX 17.1 Determining the Pattern of DNA Methylation
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
18	DNA Mutation, Repair, and Transposition
	18.1	Mutation
	18.2	Types of Mutations and Their Effects
	18.3	Mutagenesis: Origin of Mutation
	18.4	DNA Repair
	18.5	Transposable Genetic Elements
		Genetic Linkages
		BOX 18.1 Calculating Mutation Rate and Mutation Frequency
BOX 18.2 Applying Mutagenic Mechanisms to Generate Nonsense 
Mutations
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
19	Extranuclear Inheritance
	19.1	Physiological Roles of Mitochondria and Chloroplasts
	19.2	Origin of Mitochondria and Chloroplasts
	19.3	Structure and Organization of Organellar Genomes
	19.4	Mechanisms of Organellar Inheritance
	19.5	Inherited Human Mitochondrial Diseases
		Genetic Linkages
BOX 19.1 Inheritance of Mitochondrial-Associated Metabolic 
Disease in Humans
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
20	Mutational Analysis
	20.1	Types of Mutations
	20.2	Forward Genetics
	20.3	Reverse Genetics
	20.4	Advanced Genetic Analysis
	20.5	Phenocopying
		Genetic Linkages
BOX 20.1 Mapping Chromosomal Breakpoints Associated with a 
Mutant Phenotype
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
part five
Genetics and Biological Processes
21	Developmental Genetics
	21.1	Basic Concepts in Animal Development
	21.2	Pattern Formation During Drosophila Embryonic Development
	21.3	Generation of Cell Identity During Development
	21.4	Sex Determination
	21.5	Drosophila Eye Development
	21.6	Programmed Cell Death in Development
		Genetic Linkages
		BOX 21.1 Identification of Genes Involved in Signaling Pathways
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
22	Cancer Genetics
	22.1	What Is Cancer?
	22.2	Carcinogens
	22.3	The Cell Cycle
	22.4	Apoptosis
	22.5	Spontaneous Cancers
	22.6	Cancer Predisposition and Familial Cancers
	22.7	Tumor Progression
		Genetic Linkages
		BOX 22.1 Detection of K-ras Mutations in Pancreatic Cancer
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
part six
Population Genetics and Evolution
23	Population Genetics
	23.1	What Is Population Genetics?
	23.2	Frequencies of Genotypes and Alleles
	23.3	Hardy?Weinberg Equilibrium
	23.4	Selection: Shifting Allele Frequencies
	23.5	Random Genetic Drift
	23.6	Migration and Population Structure
	23.7	Nonrandom Mating
		Genetic Linkages
BOX 23.1 Application of the Hardy?Weinberg Equilibrium to a 
Human Population
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
24	Quantitative Genetics: Complex Genetic Traits
	24.1	What Is Quantitative Genetics?
	24.2	Polygenic Traits
	24.3	Statistical Tools in Quantitative Genetics
	24.4	The Nature of Continuous Variation
	24.5	Heritability
	24.6	Quantitative Genetics in Ecology
	24.7	Quantitative Trait Loci Mapping
		Genetic Linkages
		BOX 24.1 Analyzing Covariance and Predicting Values from Data
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
25	Evolutionary Genetics
	25.1	Charles Darwin and the Principles of Natural Selection
	25.2	What Is Evolutionary Genetics?
	25.3	Speciation
	25.4	Evolution at the Molecular Level
	25.5	Comparison of Genomes and Proteomes
	25.6	Applications of Evolutionary Genetics
		Genetic Linkages
		Chapter Summary Questions
		Solved Problems
		Exercises and Problems
Appendix A: Brief Answers to Selected Exercises, Problems, and Critical 
Thinking Questions
Appendix B: Suggestions for Further Reading
Glossary
Index

Library of Congress Subject Headings for this publication:

Genetics.