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Contents SUMMARY 1 Hints of a Different Way¿Case Studies in Practice-Based Evidence Overview Coverage with Evidence Development, Peter B. Bach 2 Use of Large Systems Databases, Jed Weissberg 7 Quasi-Experimental Designs for Policy Assessment, Stephen Soumerai 11 Practical Clinical Trials, Sean Tunis 16 Computerized Protocols to Assist Clinical Research, Alan H. Morris 19 References 2 The Evolving Evidence Base¿Methodologic and Policy Challenges Overview Evolving Methods: Alternatives to Large Randomized Controlled Trials, Robert M. Califf 3 Evolving Methods: Evaluating Medical Device Interventions in a Rapid State of Flux, Telba Irony 10 Evolving Methods: Mathematical Models to Help Fill the Gaps in Evidence, David M. Eddy and David C. Kendrick 14 Heterogeneity of Treatment Effects: Subgroup Analysis, Sheldon Greenfield and Richard L. Kravitz 25 Heterogeneity of Treatment Effects: Pharmacogenetics, David Goldstein 33 Broader Post-Marketing Surveillance for Insights on Risk and Effectiveness, Harlan Weisman, Christina Farup, Adrian Thomas, Peter Juhn, and Kathy Buto 36 Adjusting Evidence Generation to the Scale of Effects, Steve M. Teutsch and Marc L. Berger 40 HIPAA and Clinical Research: Protecting Privacy While Linking Patient Records, Janlori Goldman and Beth Tossell 43 References 3 Narrowing the Research-Practice Divide¿Systems Considerations Overview Feedback Loops to Expedite Study Timeliness and Relevance, Brent James 2 Electronic Health Records and Evidence-Based Practice, Walter F. Stewart and Nirav R. Shah 10 Standards of Evidence, Steven Pearson 16 Implications for Accelerating Innovation, Robert Galvin 18 References 4 New Approaches¿Learning Systems in Progress Overview Implementing Evidence-Based Practice in the VA, Joel Kupersmith 2 Practice-Based Research Networks, Robert L. Phillips, James Mold, and Kevin Peterson 11 National Quality Improvement Process and Architecture, George Isham 14 Envisioning a Rapid Learning Healthcare System, Lynn Etheredge 20 References 5 Developing the Test Bed¿Linking Integrated Delivery Systems Overview NIH and Reengineering Clinical Research, Stephen I. Katz 2 AHRQ and the Use of Integrated Service Delivery Systems, Cynthia Palmer 4 The HMO Research Network as a Test Bed, Eric B. Larson 6 Council of Accountable Physician Practices, Michael A. Mustille 13 References 6 The Patient as a Catalyst for Change Overview The Internet, E-Health, and Patient Empowerment, Janet M. Marchibroda 2 Joint Patient-Provider Management of the Electronic Health Record, Andrew Barbash 6 Evidence and Shared Decision Making, James N. Weinstein and Kate Clay 9 References 7 Training the Learning Health Professional Overview Clinicians and the Electronic Health Record as a Learning Tool, William W. Stead 2 Embedding an Evidence Perspective in Health Professions Education, Mary Mundinger 7 Knowledge Translation: Redefining Continuing Education Around Evolving Evidence, Mark V. Williams 12 References 8 Structuring the Incentives for Change Overview Opportunities for Private Insurers, Alan Rosenberg 2 Opportunities for CMS, Steve Phurrough 5 Opportunities for Pharmaceutical Companies, Wayne A. Rosenkrans Jr., Catherine Bonuccelli, and Nancy Featherstone 9 Opportunities for Standards Organizations, Margaret E. O¿Kane 12 APPENDIXES A Workshop Agenda B Biographical Sketches of Participants C Workshop Attendees D Roundtable Description
Library of Congress Subject Headings for this publication:
Medical care -- Research -- Methodology.
Delivery of Health Care -- organization & administration.
Quality of Health Care.