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Contents Superantigens: Molecular Basis for Their Role in Human Diseases Preface Section I Superantigens: What is New? 1. The Streptococcal Superantigens (John D. Fraser and Thomas Proft) 2. Staphylococcal and Streptococcal Superantigens: an Update (Patrick M. Schlievert and Gregory A. Bohach 3. Mycoplasma arthritidis-Derived Superantigen (MAM), a Unique Class of Superantigen That Bridges Innate and Adaptive Immunity (Barry C. Cole and Hong-Hua Mu) 4. Viral Superantigens in Mice and Humans (Albert K. Tai and Brigitte T. Huber) 5. Superantigens from Gram-Negative Bacteria and the Diseases That They Cause (Takehiko Uchiyama, Tohru Miyoshi-Akiyama, and Hidehiro Ueshiba) Section II Superantigen Structure and Function 6. Superantigen Architecture: Functional Decoration on a Conserved Scaffold (Vickery L. Arcus and Edward N. Baker) 7. Structural Evidence for Zinc and Peptide Dependence in Superantigen Major Histocompatibility Complex Class II Interaction (Björn Walse) 8. Superantigens: Structure, Function, and Diversity (Matthew D. Baker and K. Ravi Acharya) Section III Superantigens and Human Diseases 9. Role of Superantigens in Skin Disease (Sang-Hyun Cho and Donald Y. M. Leung) Section IV Experimental Models for Superantigen-Mediated Diseases 10. Pathogenetic Mechanisms and Therapeutic Approaches in Superantigen-Induced Experimental Autoimmune Diseases (Andrej Tarkowski) 11. Experimental Models of Superantigen-Mediated Neuropathology (Malte E. Kornhuber, Alexander Emmer, Kristina Gerlach, and M.S. Staege) 12. Novel Experimental Models for Dissecting Genetic Susceptibility of Superantigen-Mediated Diseases (Eva Medina) Section V Therapeutic Interventions in Superantigen-Mediated Diseases 13. Intravenous Immunoglobulin Therapy in Superantigen-Mediated Toxic Shock Syndrome (Anna Norrby-Teglund, Donald E. Low, and Malak Kotb) 14. Broad-Spectrum Peptide Antagonists of Superantigen Toxins (Revital Levy, Iris Nasie, Dalia Hillman, Gila Arad, and Raymond Kaempfer 15. Small Nonpeptide Inhibitors of Staphylococcal Superantigen-Induced Cytokine Production and Toxic Shock (Teresa Krakauer) 16. Countermeasures against Superantigens: Structure-Based Design of Bispecific Receptor Mimics (Goutam Gupta and Meghan Kunkel) Index
Library of Congress Subject Headings for this publication:
Superantigens -- physiology.
Bacteria -- immunology.