Bibliographic record and links to related information available from the Library of Congress catalog.
Note: Contents data are machine generated based on pre-publication provided by the publisher. Contents may have variations from the printed book or be incomplete or contain other coding.
Contents B Preface . . . . iii Contributors . . . . ix 1. Historical and Emerging Themes 1 Kevin L. Williams 2. Endotoxin Relevance and Control Overview 27 Kevin L. Williams 3. Fever and the Host Response 47 Kevin L. Williams 4. Endotoxin Structure, Function, and Activity 67 Kevin L. Williams 5. Descent of Limulus: Arthropoda and the New Biology 91 Kevin L. Williams 6. Microbial Biodiversity and Lipopolysaccharide Heterogeneity: from Static to Dynamic Models 111 Kevin L. Williams 7. Nonendotoxin Microbial Pyrogens: Lesser Endotoxins and Superantigens 133 Kevin L. Williams 8. Risk Assessment in Parenteral Manufacture 153 Edward Tidswell 9. Endotoxin as a Standard 167 Kevin L. Williams 10. Limulus Amebocyte Lysate Discovery, Mechanism, and Application 191 Kevin L. Williams 11. Limulus Amebocyte Lysate Assay Development, Validation, and Regulation 221 Kevin L. Williams 12. The Pyrogen Test 261 Karen J. Roberts vii 13. Pyrogenicity Case Studies 273 James F. Cooper and Kevin L. Williams 14. Developing Speci.cations for Active Pharmaceutical Ingredients, Excipients, Raw Materials, Sterile Pharmacy Compounds, and Nutritional Supplements 285 James F. Cooper and Kevin L. Williams 15. Depyrogenation Validation, Pyroburden, and Endotoxin Removal 301 Kevin L. Williams 16. Automation, Process Analytical Technology, and Prospective Testing 329 Kevin L. Williams 17. Limulus Amebocyte Lysate Testing of Medical Devices 361 Peter S. Lee 18. Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock 383 viii Contents Edwin S. Van Amersfoort and Johan Kuiper Index . . . . 407
Library of Congress Subject Headings for this publication:
Endotoxins -- Analysis.
Pyrogens -- Analysis.
Drugs -- Microbiology.
Endotoxins -- analysis.
Pyrogens -- analysis.
Infusions, Parenteral -- standards.