Table of contents for Endotoxins : pyrogens, LAL testing and depyrogenation / [edited by] Kevin L. Williams.

Bibliographic record and links to related information available from the Library of Congress catalog.

Note: Contents data are machine generated based on pre-publication provided by the publisher. Contents may have variations from the printed book or be incomplete or contain other coding.


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Contents
B
Preface . . . . iii
Contributors . . . . ix
1. 
Historical and Emerging Themes 1
Kevin L. Williams 
2. 
Endotoxin Relevance and Control Overview 27
Kevin L. Williams 
3. 
Fever and the Host Response 47
Kevin L. Williams 
4. 
Endotoxin Structure, Function, and Activity 67
Kevin L. Williams 
5.	
Descent of Limulus: Arthropoda and the
New Biology 91
Kevin L. Williams 
6.	
Microbial Biodiversity and Lipopolysaccharide Heterogeneity:
from Static to Dynamic Models 111
Kevin L. Williams 
7.	
Nonendotoxin Microbial Pyrogens: Lesser Endotoxins
and Superantigens 133
Kevin L. Williams 
8. 
Risk Assessment in Parenteral Manufacture 153
Edward Tidswell 
9. 
Endotoxin as a Standard 167
Kevin L. Williams 
10.	
Limulus Amebocyte Lysate Discovery, Mechanism,
and Application 191
Kevin L. Williams 
11.	
Limulus Amebocyte Lysate Assay Development, Validation, and
Regulation 221
Kevin L. Williams 
12.	
The Pyrogen Test 261
Karen J. Roberts 
vii
13.	
Pyrogenicity Case Studies 273
James F. Cooper and Kevin L. Williams 
14.	
Developing Speci.cations for Active Pharmaceutical Ingredients,
Excipients, Raw Materials, Sterile Pharmacy Compounds, and
Nutritional Supplements 285
James F. Cooper and Kevin L. Williams 
15.	
Depyrogenation Validation, Pyroburden, and Endotoxin Removal 301
Kevin L. Williams 
16.	
Automation, Process Analytical Technology, and Prospective Testing 329
Kevin L. Williams 
17.	
Limulus Amebocyte Lysate Testing of Medical Devices 361
Peter S. Lee 
18.	
Receptors, Mediators, and Mechanisms Involved in Bacterial
Sepsis and Septic Shock 383
viii	Contents
Edwin S. Van Amersfoort and Johan Kuiper 
Index . . . . 407

Library of Congress Subject Headings for this publication:

Endotoxins -- Analysis.
Pyrogens -- Analysis.
Limulus test.
Drugs -- Microbiology.
Endotoxins -- analysis.
Pyrogens -- analysis.
Infusions, Parenteral -- standards.
Limulus Test.