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Preface ix 1. Heat Shock Proteins: Expression and Functional Roles in Nerve Cells and Glia 1 Christiane Richter-Landsberg Introduction 1 Heat Shock Proteins in Nerve Cells and Glia 4 Concluding Remarks 8 2. Small Heat Shock Proteins and the Cytoskeleton: Their Role in Inclusion Body Formation in Glial Cells 13 Christiane Richter-Landsberg and Olaf Goldbaum Introduction 13 The Cytoskeleton in Nerve Cells and Glia 14 Interaction of Small Heat Shock Proteins with Cytoskeletal Proteins 15 sHSPs and Inclusion Body Formation in Glial Cells 19 Concluding Remarks 20 3. The Role of Hsps in Neuronal Differentiation and Development 25 Kate Reed Herbert, Afshin Samali and Adrienne Gorman Introduction 25 Hsp Expression during Development of the Nervous System 26 Transcriptional Regulation of Hsp Expression during Neuronal Development and Differentiation 28 Possible Roles of Hsps in Neuronal Differentiation and Development of the Nervous System 28 Concluding Remarks 33 4. Heme Oxygenase as a Therapeutic Funnel in Nutritional Redox Homeostasis and Cellular Stress Response: Role of Acetylcarnitine 39 Vittorio Calabrese, Giovanni Pennisi, Menotti Calvani, D. Allan Butterfield, Cesare Mancuso and Anna Maria Giuffrida Stella Introduction 39 Heme Oxygenase-1 40 HO-1, Oxidative Stress and Neurodegenerative Disorders 43 Acetylcarnitine 45 Conclusions and Perspectives 47 5. Heat Shock Proteins and the Regulation of Apoptosis 53 Una FitzGerald, Adrienne M. Gorman and Afshin Samali Introduction to Apoptosis 53 Hsp27 and Hsp70, the Anti-Apoptotic Heat Shock Proteins 55 Apoptosis, Hsps and Neurodegenerative Disorders 58 Concluding Remarks 62 6. Assembly of Protein Aggregates in Neurodegeneration: Mechanisms Linking the Ubiquitin/Proteasome Pathway and Chaperones 67 Sha-Ron Pierre, Vita Vernace, Zhiyou Wang and Maria E. Figueiredo-Pereira Introduction 67 Protein Degradation by the UPP 68 Potential Mechanisms for the Formation of Ubiquitin-Protein Aggregates 71 Subcellular Distribution of Ubiquitin-Protein Aggregates 75 Concluding Remarks 76 7. The Role of Heat Shock Proteins during Neurodegeneration in Alzheimer's, Parkinson's and Huntington's Disease 81 Andreas Wyttenbach and Andr¿ Patrick Arrigo Introduction 81 Common Mechanisms Leading to Impaired Neuronal Function and Death and the Role of HSPs 88 Heat Shock Proteins and Therapy 96 Conclusions 97 8. Heat Shock Proteins in Multiple Sclerosis 101 Celia F. Brosnan, Luca Battistini and Krzysztof Selmaj Introduction 101 The Small Heat Shock Proteins 102 The HSP60 Family 104 The HSP70 Family 106 Concluding Remarks 108 Index 113
Library of Congress Subject Headings for this publication:
Heat shock proteins.
Nerve tissue proteins.
Neurons -- physiology.
Neuroglia -- physiology.