Table of contents for Biocatalysts in the pharmaceutical and biotechnology industries / edited by Ramesh Patel.

Bibliographic record and links to related information available from the Library of Congress catalog.

Note: Contents data are machine generated based on pre-publication provided by the publisher. Contents may have variations from the printed book or be incomplete or contain other coding.


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Chapter 1: Nitrilases and Nitrile Hydratases
	 Robert DiCosimo 
 DuPont Central Research and Development, Wilmington, Delaware
Dr. Robert Dicosimo						
Dupont Central Research and Development
Experimental Station
Building 328/260B
P. O. Box 80328
Wilmington, DE 19880-0328				
E-mail: Robert.DiCosimo@usa.dupont.com
Chapter 2 : Biocatalytic Deracemization: Dynamic Resolution, Stereoinversion, 
 Enantioconvergent Processes and Cyclic Deracemization
 Yolanda Simeó, Wolfgang Kroutil and Kurt Faber
 University of Graz, Graz, Austria
Contact author :
Prof. Dr. Kurt Faber
Department of Chemistry
Institute of Organic and Bio-Organic Chemistry
University of Graz
Heinrichstrasse 28, A-8010 Graz
Austria
E-mail: Kurt.Faber@uni-graz.at
Chapter 3: A Decade of Biocatalysis at Glaxo Wellcome
 Mahmoud Mahmoudian
 Director of Biotechnology, Eastman Chemical Company, USA
 P.O. Box 1972, Kingsport, Tennessee 37662-5150, USA; 
 Phone: 423 224 7568 (work), 423 928 7725 (home); Fax: 423 229 3896 
 (work), 423 928 7725 (home)
 Email: mmahmoudian@eastman.com (work)
 Contact author: Dr. Mahmoud Mahmoudia
Chapter 4: Biocatalysis for Synthesis of Chiral Pharmaceutical Intermediates
		Ramesh N. Patel
Process Research & Development
		 Bristol-Myers Squibb
		 One Squibb Drive
		 New Brunswick, NJ 08903
		 USA 
Contact author: Ramesh N. Patel
		Phone: 732-227-6213
		Fax: 732-227-3994
		E mail: ramesh.patel@bms.com
		Contact Author: Dr. Ramesh N. Patel
Chapter 5: Directed Evolution of Lipases and Esterases for Organic Synthesis
	 Aurelio Hidalgo, Uwe T. Bornscheuer
Department of Technical Chemistry and Biochemistry, Institute for Chemistry and
Biochemistry, Greifswald University, Greifswald, Germany.
Address: Soldmannstr. 16, 17847 Greifswald, Germany
Phone: +49 3834 864367
Fax: +49 3834 8680066
Email: uwe.bornscheuer@uni-greifswald.de
Contact author: Uwe T. Bornscheuer
Chapter 6: Flavin containing Oxidative Biocatalysts
 Marco W. Fraaije+ , Williem J. H. van Berkel*
#Laboratory of Biochemistry, University of Groningen, The Netherlands
Nijenborgh 4, 9747 AG Groningen, The Netherlands. Phone: +31-50-3634345; 
Fax: +3150-3634165; Email: m.w.fraaije@rug.nl
*Laboratory of Biochemistry, Wageningen University, The Netherlands
Dreijenlaan 3, 6703 HA Wageningen, The Netherlands. Phone: +31-317-482861; 
Fax: +31-317-484801; Email: willem.vanberkel@wur.nl
Contact author: 	Willem J.H. van Berkel
willem.vanberkel@wur.nl
Chapter 7: Preparation of Chiral Pharmaceuticals through Enzymatic Acylation of Alcohols 
 Amines
	 Vinvente Gotor Fernandez, Francisca Rebollledo, Vincente Gotor
 Departamento de Química Org nica e Inorg nica. Facultad de Química. 
 Universidad de Oviedo. 33006-Oviedo, Spain
 Contact author: Prof. Dr. Vicente Gotor 
Departamento de Química Org nica e Inorg nica 
Facultad de Química 
Universidad de Oviedo 
Avenida Juli n de Clavería, 8 
33006-Oviedo (Asturias) 
ESPA; A-SPAIN 
E-mail: VGS@fq.uniovi.es
Chapter 8: Dynamic Kinetic Resolution and Asymmetric Transformations by
 Enzyme-Metal Combination
 Mahn-Joo Kim, Yangsoo Ahn, and Jaiwook Park
Affiliation: Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology
Address: San-31 Hyojadong, Pohang, Kyongbuk 790-784, Korea
Phone: 82-54-279-2112, Fax: 82-54-279-0654
Email: mjkim@postech.ac.kr, ysahn@postech.ac.kr, pjw@postech.ac.kr
Contact author: Mahn-Joo Kim
Chapter 9: Biotransformation of Natural or Synthetic Compounds for The Generation of 
 Molecular Diversity
 Robert Azerad
Affiliation : Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601, Université René Descartes-Paris V, Paris , France
Address : 45 rue des Sts Pères, 75006 Paris, France
Phone : + 33 1 42 86 2, Fax : + 33 1 42 86 83 87
 Email : Robert.azerad@univ-paris5.fr
Chapter 10: Applications of Aromatic Hydrocarbon Dioxygenases
Rebecca E. Parales1* and Sol M. Resnick2
Section of Microbiology, University of California, Davis, CA 956161 and
Biotechnology R&D, The Dow Chemical Company, San Diego, CA 921212
* Corresponding author. Mailing Address: Section of Microbiology, 226 Briggs Hall, 1 Shields Ave. University of California, Davis, CA 95616. Phone: 530-754-5233 Fax: 530-752-9014 Electronic mail address: reparales@ucdavis.edu
Chapter 11: A Genomic Approach to Investigating Bakers¿ Yeast Reductions
Jon D. Stewart
Affiliation: Department of Chemistry, University of Florida, Gainesville FL USA
Address: 3328 NW 110th Terrace, Gainesville, FL 32606
Phone: 352-846-0743
Fax: 352-846-2095
E-mail: jds2@chem.ufl.edu
Contact author: Jon D. Stewart
Chapter 12: Immobilization of Enzymes as Cross-linked Enzyme Aggregates (CLEAs):
 A Simple Method for Improving Performance
Prof. Dr. Roger Sheldon
Laboratory of Organic Chemistry and Catalysis
Delft University of Technology
Julianalaan 136
2628 BL Delft
The Netherlands
E-mail: roger@sheldon.nl
Chapter 13: Biotechnology Applications of Aldolases 
 
Wolf-Dieter Fessner & Stefan Jennewein
Affiliation: Institut für Organische Chemie und Biochemie, Technische Universität Darmstadt, Germany.
Address: Petersenstraße 22, 64285 Darmstadt
Email: fessner@tu-darmstadt.de 
Chapter 14: Enzymatic Synthesis of Modified Nucleoside
 Luís A. Condezo; Jesús Fern ndez-Lucas; Carlos A. García-Burgos, 
 Andrés R. Alc ntara; José V. Sinisterra*
Affiliation: Biotransformations Group. Organic and Pharmaceutical Chemistry Department. Pharmacy Faculty. Complutense University.. 
Address: Plaza Ramón y Cajal s/n. 28040Madrid. Spain
Phone: 34-91-3941820
Fax: 34-91-3941822
Email: jvsgago@farm.ucm.es
Contact author. Jose V. Sinisterra 
Chapter 15: Biocatalytic Reduction of Carboxylic Acids: Mechanism and Applications
 Padmesh Venkitasubramanian, Lacy Daniels and John P. N. Rosazza
Affiliation: Center for Biocatalysis and Bioprocessing, University of Iowa, Iowa City, 
Iowa USA
Address: 2501 Crosspark Road, Suite C100, Oakdale Research Park, University of Iowa, Iowa City, Iowa 52242-5000
Phone: 319-335-4902,FAX: 319-335-4901
Email: john-rosazza@uiowa.edu Contact author: John P. N. Rosazza
Chapter 16: Dehalogenases in Biodegradation and Biocatalysis
Dick B. Janssen
Affiliation:Biotransformation and Biocatalysis Laboratory, 
Groningen Biomolecular Sciences and Biotechnology Institute, 
University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Phone: (00)31-50-3634209, Fax: (00)31-50-3634165, Email: d.b.janssen@rug.nl.
Chapter 17: Enzymatic Synthesis of Sugar Esters and Oligosaccharides from Renewable
 Resources
 A. Ballesteros, F.J. Plou, M. Alcalde, M. Ferrer, H. García-Arellano, 
 D. Reyes-Duarte and I. Ghazi
Departamento de Biocat lisis, Instituto de Cat lisis y Petroleoquímica, CSIC.
Address: Marie Curie 2, Cantoblanco, 28049 Madrid, Spain.
Phone: 34-91-5854808. Fax: 34-91-5854760
E-mail: a.ballesteros@icp.csic.es
Contact author: Antonio Ballesteros
Chapter 18: Efficient Methods and Instrumentation for Engineering Custom Enzymes 
 Steven J. Robles, William J. Coleman and Mary M. Yang
Affiliation: KAIROS Scientific Inc., 10225 Barnes Canyon Rd., Suite A110, San Diego, CA, 92121, USA.
Phone: 858-626-8170
Email: myang@kairos-scientific.com
Contact author: Mary M. Yang
Chapter 19: Deaminating Enzymes of the Purine Cycle as Biocatalysts for Chemo-enzymatic 
 Synthesis and Transformation of Antiviral Agents Structurally Related to Nucleosides 
Enzo Santaniello*, Pierangela Ciuffreda, Laura Alessandrini
Affiliation: Dipartimento di Scienze Precliniche LITA Vialba, Università degli Studi di Milano, Italia
Address: Via G. B. Grassi, 74 ¿ 20157 Milano, Italia
Phone: +39 0250319691
Fax: +39 0250319694
Contact author : Enzo Santaniello
e-mail: Enzo.Santaniello@unimi.it
Chpater 20: Microbial and enzymatic processes for the production of chiral compounds
Kohsuke Honda, Takeru Ishige, and Sakayu Shimizu
Affiliation: Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Address: Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto, 606-8502, Japan.
Phone: +81-75-753-6115
Fax: +81-75-753-6128
Email: sim@kais.kyoto-u.ac.jp
Contact author: Sakayu Shimizu
Chapter 21: Discovery of Arylmalonate Decarboxylase and Conversion of the Function by 
Rational design
Kenji Miyamoto and Hiromichi Ohta
Affiliation : Department of Biosciences and Informatics, Keio University
Address : 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan
Phone : +81-45-566-1703 (Hiromichi Ohta)
+81-45-566-1786(Kenji Miyamoto)
 Fax : +81-45-566-1551 (Hiromichi Ohta)
 +81-45-566-1789 (Kenji Miyamoto)
 Email : hohta@bio.keio.ac.jp (Hiromichi Ohta)
 kmiyamoto@bio.keio.ac.jp (Kenji Miyamoto)
Contact author : Hiromichi Ohta
Chapter 22: Chemoenzymatic Preparation of Enantiopure Building Blocks of Synthetic Utility
Kenji Mori
Affiliation : Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology
Contact Address : 	Emeritus Professor, the University of Tokyo, 1-20-6-1309, Mukogaoka, Bunkyo-ku, Tokyo 113-0023, Japan
Phone :		81-3-3816-6889
Fax :		81-3-3816-6889
E-Mail :		kjk-mori@arion.ocn.ne.jp
Contact author :	Prof. Kenji Mori
 
Chapter 23: Stereoselective modifications of polyhydroxylated steroids
 Elena Fossati and Sergio Riva
Affiliation: Istituto di Chimica del Riconoscimento Molecolare, C.N.R., Milano, Italy
Address: Via Mario Bianco 9, 20131, Milano, Italy
Phone: ++39 02 2850 0032
Fax: ++39 02 2890 1239
Email: sergio.riva@icrm.cnr.it
Contact author : Sergio Riva
Chapter 24: Recent Developments in Enzymatic Acyloin Condensations
 Owen Ward and Ajay Singh
Affiliation: Department of Biology, University of Waterloo, 
Waterloo, Ontario, Canada
Address: 200 University Avenue West, Waterloo, Ontario, Canada, N2L 3G1
Tel: +1-519-888-4567 Ext. 2427
Fax: +1-519-746-0614;
E-mail: opward@sciborg.uwaterloo.ca
Contact author: Dr. Owen P. Ward
Chapter 25: Synthesis of Chiral Alcohols with Carbonyl Reductase Library
 and Robust NAD(P)H Regenerator
Hiroaki Yamamoto1) and Akinobu Matsuyama2)
Affiliation: 1) Lifescience Development Center, CPI Company, Daicel Chemical Industries, Ltd., 2) Corporate Development Center, Daicel Chemical Industries, Ltd.
Address: Tsukuba Research Center, 27 Miyukigaoka, Tsukuba 305-0841, Japan
Phone: +81-29-856-1322
Fax: +81-29-856-1323
Email: h-yamamoto@daicel.co.jp
Contact author. Hiroaki Yamamoto
Chapter 26: Comparative analysis of chemical and biocatalytic syntheses of drug intermediates 
 Michael J. Homann, Wen-Chen Suen, Ningyan Zhang¿, and Aleksey Zaks*
 Schering-Plough Research Institute, 1011 Morris Avenue, Union, NJ 07083, USA 
 e-mail: alex.zaks@spcorp.com
Chapter 27: Industrial processes using lyases for C-C, C-N, and C-O-bond formation
Martina Pohl1 and Andreas Liese2
Affiliations: 
1 Institute of Molecular Enzyme Technology, Heinrich-Heine University of Duesseldorf, 
Address: D-52426 Jülich, Germany
Email: ma.pohl@fz-juelich.de
2 Institute of Biotechnology II, Technical University of Hamburg-Harburg
Address: Denickestr. 15, D-21073 Hamburg, Germany
Email: liese@tuhh.de
Contact author: Andreas Liese
Chapter 28: State of the Art and Applications in Stereoselective Synthesis of Chiral Cyanohydrns
	Franz Effenberger, Siegfried Forster and Christoph Kobler
	Institute of Organic Chemistry
University of Stuttgart
Pfaffenwaldring 55, D-70596 Stuttgart
Germany
Contact author: Franz Effenberger
E-mail: franz.effenberger@oc.uni-stuttgart.de
Chapter 29: Chiral Switches: Problems, Strategies, opportunities and Experiences
Rene Csuk
Institute of Organic Chemistry
Martin-Luther-University Halle-Wittenberg
Kurt-Mothes-Strasse 2
D-06120 Halle (Saale)
Germany
Contact Author: Rene Csuk
Rene.csuk@chemie.uni-halle.de
Chapter 30: Enzyme Evolution for Chemical Process Applications
	Gjalt W. Huisman and James J. Lalonde
	Codexis Inc.
	200 Penobscot Drive
	Redwood City
	CA 94063
	USA
	Contact Author: gjalt.huisman@codexis.com
Chapter 31: Biocatalytic Routes to Non-Racemic Chiral Amines
	 Nicholas J. Turner and Reuben Carr
Contact Author: Nicholas J. Turner*
School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Email: Nicholas.turner@manchester.ac.uk
Reuben Carr
Ingenza Ltd., Joseph Black Building, King¿s Buildings, West Mains Road, Edinburgh, 
EH9 3JJ, UK.
Email: r. carr@ingenza.com
Chapter 32: Enantioselective Biocatalytic Reduction of Ketones for the Synthesis of Optically Active Alcohols
 Stefan Buchholz, Harald Gröger
 Contact Author: Stefan Buchholz
 Degussa AG
 Project House ProFerm
 Rodenbacher Chaussee 4
 63403 Hanau-Wolfgang
 Germany
 E-Mail: stefan.buchholz@degussa.com

Library of Congress Subject Headings for this publication:

Enzymes -- Biotechnology.
Biotechnology -- Industrial applications.
Catalysis.
Enzymes.
Biotechnology -- methods.
Pharmaceutical Preparations -- chemical synthesis.