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Contents Preface Introduction - Drug Discovery in the 21st Century: An Introduction Shayne C. Gad Chapter 1 - Natural Products Charles B. Spainhour Chapter 2 - Cancer Cell Proteomics Using Molecular Aptamers Weihong Tan, Zehui Cao, Dihua Shangguang Chapter 3 - Molecular Similarity Methods and QSAR Models as Tools for Virtual Screening Jürgen Bajorath Chapter 4 - Systems Biology: Applications in Drug Discovery Sean Ekins, Andrej Bugrim, Yuri Nikolsky, Tatiana Nikolskaya Chapter 5- High Throughput Flow Cytometry Larry A. Sklar, Peter C. Simons, Anna Waller. Sean M. Biggs, Susan M. Young, Marius Olah, Cristian Bologa, Tudor I. Oprea, Eric R. Prossnitz, Bruce S. Edwards Chapter 6 - Combining NMR Spectral Information with Associated Structural Features to Form Computationally Non-Intensive, Rugged, and Objective Models of Biological Activity Richard Beger, Dan A. Buzatu, Jon G. Wilkes Chapter 7 - Using Microsoft Excel as a Laboratory Data Management Tool A. Erik Rubin, Mark F. Russo, William Neil Chapter 8 - The Age of Regulation Sandy Weinberg and Gerald J. Whartenby Chapter 9 - Simultaneous Screening of Multiple Cell Lines Using the CellCardtm System Oren E. Beske Chapter 10 - Protein X-Ray Crystallography in Drug Discovery Peter Nollert, Michael D. Feese, Bart L. Staker, Hidong Kim Chapter 11 - Biological and Chemistry Assays Available During Drug Discovery and Developability Assessment Duane B. Lakings Chapter 12 - Strategies and methods in monitoring and targeting protein-protein interactions Arianna Loregian and Giorgio Palù Chapter 13 - High Throughput Screening: Evolution of Technology and Methods Martyn N. Banks, Angela M. Cacace, Jonathan O'Connell, John G. Houston Chapter 14 - Metal-Enhanced Fluorescence: Application to High-Throughput Screening and Drug Discovery Kadir Aslan, Ignacy Gryczynski , Joanna Malicka , Joseph R. Lakowicz , Chris D. Geddes Chapter 15 - Methods for the Design and Analysis of Replicate-Experiment Studies to Establish Assay Reproducibility and the Equivalence of Two Potency Assays Brian J. Eastwood, Amy K. Chesterfield, Mary C. Wolff, Christian C. Felder Chapter 16 - Coupled Luminescent Methods in Drug Discovery: Three-Minute Assays for Cytotoxicity and Phosphatase Activity Michael J.Corey and Robert J. Kinders Chapter 17 - Design and Pharmaceutical Applications of Prodrugs Tomi Jarvinen, Jarkko Rautio, Mar Masson, Thorsteinn Loftsson Chapter 18 - GABA and Glutamate Receptor Ligands and Their Therapeutic Potential in CNS Disorders Ulf Madsen, Hans Bräuner-Osborne, Jeremy R. Greenwood, Tommy N. Johansen, Povl Krogsgaard-Larsen, Tommy Liljefors, Mogens Nielsen, Bente Frolund Chapter 19 - Cardiac Sarcolemmal ATP-sensitive Potassium Channel Antagonists: Novel Ischemia-selective Antiarrhythmic Agents George E. Billman Chapter 20 - Factors Influencing the Efficacy of Mediator-Specific Anti-inflammatory, Glucocorticoid and Anti-Coagulant Therapies for Sepsis Peter C. Minneci, Katherine J. Deans, Michael Haley, Xizhong Cui, Charles Natanson, Peter Q. Eichacker Chapter 21 - Combinatorial Chemistry in the Drug Discovery Process Nathan T. Ross, Brian R. McNaughton, and Benjamin L. Miller Chapter 22 - Herbal Medicines and Animal Models of Gastrointestinal Diseases C.H. Cho and J.K.S. Ko Chapter 23 - Endocrine and Metabolic Agents Brian L. Furman Chapter 24 - Respiratory Viruses Paul D. Olivo Chapter 25 - Strategies in the Design of Antiviral Drugs Erik De Clercq and Piet Herdewijn Chapter 26 - Protein Kinase Inhibitors in Drug Discovery Keykavous Parang and Gongqin Sun Chapter 27 - RNA-Based Therapies Ingmar Hoerr and Steve Pascolo Chapter 28 - Novel Imaging Agents for Molecular MR Imaging of Cancer Dmitri Artemov and Zaver M. Bhujwalla Chapter 29 - Genomics-Based Drug Discovery Spyro Mousses Chapter 30 - Cancer Drug Discovery Susan Mooberry
Library of Congress Subject Headings for this publication:
Drugs -- Research -- Handbooks, manuals, etc.
Drug development -- Handbooks, manuals, etc.
Drugs -- Design -- Handbooks, manuals, etc.
Pharmaceutical chemistry -- Handbooks, manuals, etc.