Table of contents for Discovering cell mechanisms : the creation of modern cell biology / William Bechtel.

Bibliographic record and links to related information available from the Library of Congress catalog.

Note: Contents data are machine generated based on pre-publication provided by the publisher. Contents may have variations from the printed book or be incomplete or contain other coding.

Table of Contents
1. Introduction: Cell Mechanisms and Cell Biology
1. A Different Kind of Science
2. The Organization of Science into Disciplines
3. The New Discipline of Cell Biology
2. Explaining Cellular Phenomena through Mechanisms
1. Historical Conceptions of Mechanism
2. 20th Century Conceptions of Mechanism
3. Current Conceptions of Mechanism
Mechanisms explain phenomena
Component parts and component operations
Organization and orchestration
4. Representing and reasoning about mechanisms
5. Levels of Organization and Reduction
6. Organization: From Cartesian to Biological Mechanisms
7. Discovering and Testing Models of Mechanisms
Identifying working parts
Identifying component operations
Localizing opertions in parts
Testing models of mechanisms
8. Conclusions
3. The Locus of Cell Mechanisms: Terra Incognita between Cytology and
1. Cytological Contributions to Discovering Cell Mechanisms up to 1940
Cytology in the 19th Century
Cell Membranes (1825--1935)
The Mitochondrion (1890--1925)
Ergastoplasm or Basophilia (1900--1930)
The Golgi Apparatus (1900--1940)
The State of Cytology Circa 1940
2. Biochemical Contributions to Discovering Cell Mechanisms up to 1940
Foundations for Biochemistry in the 19th Century
The Emergence of Biochemistry in the 20th Century
Alcoholic and Lactic Acid Fermentation (1895--1940)
Aerobic Cellular Respiration (1910--1940)
The State of Biochemistry Circa 1940
3. The Need to Enter the Terra Incognita between Cytology and Biochemistry
4. Creating New Instruments and Research Techniques to Study Cell Mechanisms
1. The Epistemology of Evidence: Judging Artifacts
2. The Ultracentrifuge and Cell Fractionation
Breaking Cell Membranes
Choice of Media
Centrifugation Regime
Interpreting Fractionation Results
3. The Electron Microscope and Electron Microsopy
Obtaining Sufficiently Thin Specimens
Altering the Specimen to Survive Microscopy and Generate an Image
4. A Case Study of an Artifact Charge
5. Equipped with New Instruments and Techniques to Enter Terra Incognita
5. Entering the Terra Incognita between Biochemistry and Cytology: Putting New
Research Tools to Work in the 1940s
1. First Steps Towards Cell Biology at the Rockefeller Institute: Claude's
Introduction of Cell Fractionation
2. Robert Bensley: An Alternative Approach to Fractionation
3. Competing Interpretations of Fractions from Normal Cells
4. Linking Claude's Microsomes to Protein Synthesis
Brachet: Selective Staining of RNA and Correlation with Protein
Caspersson: Spectrographic Analysis, RNA, and Protein Synthesis
5. Adding a Biochemical Perspective to the Rockefeller Laboratory
6. Adding Electron Microscopy as a Tool
7. The State of Cell Studies at the End of the 1940s
6. New Knowledge: The Mechanisms of the Cytoplasm
1. The Mitochondrion
Biochemists Confront Particulate Structure: Mitochondrial Enzyme
More Structure: The Discovery of the Cristae of the Mitochondrion
A Competing Perspective on Mitochondrial Morphology
Biochemists Further Fractionate Mitochondria
One More Piece of Structure and a Proposal as to its Function
Radical Reconceptualization of Oxidative Metabolism
2. Microsomes, the Endoplasmic Reticulum, and Ribosomes
From Lace--Like Reticulum to Endoplasmic Reticulum
Dissenting Voices
Securing the Connection to Protein Synthesis
Integrating Morphology and Biochemistry
Naming the Ribosome
Going to a Lower Level: Decomposing the RNA Machinery
Transporting Newly Sequenced Polypeptides
3. Two Additional Organelles
The Golgi Apparatus
The Lysosome
7. Giving Cell Biology an Institutional Identity
1. Creation of the Journal of Biophysical and Biochemical Cytology
2. Creation of the American Society for Cell Biology

Library of Congress Subject Headings for this publication:

Cytology -- history.
Cell Physiology.
Cytological Techniques.