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Contents I. Perspective on Immunological mechanisms underlying adjuvant activity 1) Unravelling "the immunologist's dirty little secret" Virgil Schijns II. Host-derived immunopotentiators 2) Dendritic cells as targets and tools in vaccines Filippo Belardelli, Imerio Capone and Paoloa Rizza 3) Host derived molecules and antibodies against them as adjuvants Tom Barr, Jennifer Carlring, Andrew W. Heath, III. Natural and synthetic immunopotentiators 4) Immune potentiator mechanisms Nick Valiante 5) CpG Oligodeoxynucleotides as vaccine adjuvants Michael J. McCluskie and Risini D. Weeratna 6) Toll-like receptor 4 agonists as vaccine adjuvants David Persing, Patrick McGowan, Jay T. Evans, Christopher Cluff, Sally Mossman, David Johnson and Jory R. Baldridge 7) Immunomodulatory adjuvants from Quillaja saponaria Charlotte Read Kensil IV. Particulate immunopotentiators and delivery systems 8) Microparticles as vaccine delivery systems Derek T. O'Hagan 9) MF59: A safe and potent adjuvant for human use Audino Podda , Giuseppe Del Guidice and Derek T. O'Hagan 10) Development and evaluation of AS04, an novel an improved adjuvant system containing MPL and aluminium salt Nathalie Garcon, Marcelle van Mechelen and Martine Wettendorf 11) Virosomes for vaccine delivery Ian C. Metcalfe and Reinhard Gluck 12) The ISCOMATRIXTM adjuvant Debbie Drane and Martin Pearse 13) Mineral adjuvants Erik B. Lindblad V. Mucosal/ non-parenteral adjuvants 14) Mucosal Adjuvants Based On Cholera Toxin and Escherichia Coli Heat-Labile Enterotoxin Jan Holmgren 15) Transcutaneous Immunization using the Heat-labile Enterotoxin of E. coli as an Adjuvant Richard T. Kenney and Gregory M. Glenn VI. Th-1/ CTL adjuvants 16) T cell adjuvants and novel strategies for their identification Philippe Moingeon VII. Adjuvants in non-infectious disease vaccines 17) Vaccination to treat non-infectious diseases: surveying the opportunities Stephen W. Martin and Martin F Bachmann VIII. Clinical Practice 18) Clinical evaluation of adjuvants Robert Edelman and Jakub K Simon 19) Non-clinical safety assessment of vaccines Elizabeth M Sutkowski and Marion F Gruber
Library of Congress Subject Headings for this publication:
Immunological adjuvants.
Immune response -- Regulation.
Vaccines.
Vaccines -- immunology.
Adjuvants, Immunologic.
Drug Delivery Systems.
Immunotherapy.