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ANNALS OF THE NEW YORK ACADEMY OF SCIENCES Volume 1052 June 2005 THE FUTURE OF HORMONE THERAPY: WHAT BASIC AND CLINICAL STUDIES TEACH US Editors Meharvan Singh and James W. Simpkins This volume is the result of a conference entitled The Future of Estrogen and Hormone Therapy in Postmenopausal Women, sponsored by the North Texas Health Science Center's Office of Professional and Continuing Education and the New York Acdemy of Sciences, held on November 5-7, 2004, in Fort Worth, Texas. CONTENTS Introduction. By Meharvan Singh and James W. Simpkins Part I. The Appropriate Population of Women to Study Surgical Menopause, Estrogen, and Cognitive Function in Women: What Do the Findings Tell Us? By Babara Sherwin. Menopausal Hot Flashes and Development of Cognitive Impairment. By Anna Ratka. Depression, the Perimenopause, and Estrogen Therapy. By Peter J. Schmidt. Part II. The Therapeutic Window for Hormone and/or Estrogen Therapy Is the Estrogen Controversy Over? Deconstructing the Women's Health Initiative Study: A Critical Evaluation of the Evidence. By S. Mitchell Harman, Frederick Naftolin, Eliot A. Brinton, and Debra R. Judelson. Investigative Models for Determining Hormone Therapy-Induced Outcomes in Brain: Evidence in support of a Healthy Cell Bias of Estrogen Action. By Roberta Diaz Brinton. Estrogen: A Neuroprotective or Proinflammatory Hormone? Emerging Evidence from Reproductive Aging Models. By Farida Sohrabji. Part III: The Appropriate Formulations of Hormone/Estrogen Therapy Clinical Pharmacology and Differential Cognitive Efficacy of Estrogen Preparations. By Carey E. Gleason, Cynthia M. Carlsson, Sterling Johnson, Craig Atwood, and Sanjay Asthana. Development of 17(alpha)-Estradiol as a Neuroprotective Therapeutic Agent: Rationale and REsults from a Phase I Clinical Study. By James A. Dykens, Walter H. Moos, and Neil Howell. Estrogen and tghe Brain: Beyond ER-(alpha), ER-(beta), and 17(beta)-Estradiol. By C. Dominique Toran-Allerand. Mechanisms of Progesterone-Induced Neuroprotection. By Meharvan Singh. The Case for Progesterone. By Donald G. Stein. Part IV: The Most Appropriate Design for Clinical Trials that Address the Efficacy of Hormone/Estrogen Therapy Methodological Issues in Estrogen Treatment Trials for Alzheimer's Disease. By Ruth A. Mulnard. A Systematic Review of Clinical Trials of Hormone Therapy on Cognitive Function: Effects of Age at Initiation and Progestin Use. By Pauline M. Maki. Part V: Appropriate Surrogate Markers of Neurological Decline and Best Experimental Models to Assess the Efficacy of Hormone/Estrogen Therapy Estrogen Bows to a New Master: The Role of Gonadotropins in Alzheimer Pathogenesis. By Kate M. Webber, Gemma Casadesus, Michael W. Marlatt, George Perry, Clive R. Hamlin, Craig S. Atwood, Richard L. Bowen, and Mark A. Smith. Estradiol Prevents Neural Tau Hyperphosphorylation Characteristic of Alzheimer's Disease. By Margarita Alvarez-de-la-Rosa, Ivaldo Silva, Jon Nilsen, M.M. Perez, Luis Miguel Garcia-Segura, Jesus Avila, and Frederick Naftolin. Estrogen and Cerebrovascular Stroke: What Do Animal Models Teach Us? By Phyllis M. Wise. Role of Nonfeminizing Estrogens in Brain Protection from Cerebral Ischemia: An Animal Model of Alzheimer's Disease Neuropathology. By James W. Simpkins, Yi Wen, Evelyn Perez, Shaohua Yang, and Xiaofei Wang. PROKAI paper Concluding Remarks. By James W. Simpkins and Meharvan Singh. Index of Contributors
Library of Congress Subject Headings for this publication:
Hormone therapy -- Congresses.
Estrogen Replacement Therapy -- Congresses.
Cardiovascular Diseases -- Congresses.
Dementia -- Congresses.
Gonadal Steroid Hormones -- therapeutic use -- Congresses.
Treatment Outcome -- Congresses.