Table of contents for Voltage-gated calcium channels / [edited by] Gerald W. Zamponi.

Bibliographic record and links to related information available from the Library of Congress catalog.

Note: Contents data are machine generated based on pre-publication provided by the publisher. Contents may have variations from the printed book or be incomplete or contain other coding.


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		Preface	xiv
	1.	Ca2+ Chemistry, Storage and Transport in Biologic Systems: 
An Overview	1
Tashi G. Kinjo and Paul P.M. Schnetkamp
Why Ca2+ Unique Chemical and Physical Features	1
Ca2+ Evolution a Rejection from Cytoplasm	2
Ca2+ Signaling and Storage the Endoplasmic Recticulum	2
The Role of Ca2+ within the ER	3
ER Heterogeneity Ca2+ Tunneling Versus 
Ca2+ Compartmentalization	3
Ca2+ Signaling and Storage Mitochondria	4
Mitochondrial Ca2+ Uptake Function and Effects	4
Ca2+ Buffering; Cytosolic and Lumenal	5
Channels that Lead to an Increase in Cytosolic Ca2+	5
Intracellular Ca2+ Release Channels	6
Plasma Membrane Ca2+ Channels	7
Cyclic Nucleotide-Gated Channels	7
P2X Receptors	7
SOCE and the TRP Gene Family	8
Mechanisms of Store-Operated Ca2+ Entry	8
Mechanisms to Lower Cytosolic Ca2+	8
PMCA Gene Family	9
SERCA Gene Family	9
NCX Gene Family	9
NCKX Gene Family	9
	2.	Monitoring Intracellular Ca2+ in Brain Slices 
with Fluorescent Indicators	12
Sean J. Mulligan and Brian A. MacVicar	
Ca2+ Sensitive Fluorescent Chemical Indicators	12
Single-Wavelength Probes	13
Dual-Wavelength Ratiometric Probes	15
Ca2+ Binding Affinity	16
Ca2+ Indicator Form	18
Dextran Conjugates	18
AM-Esters	20
Quantitative Measurement of [Ca2+]i 	21
	3.	A Brief History of Calcium Channel Discovery	27
Richard W. Tsien and Curtis F. Barrett
The Key Role of Ca2+ Channels in Cellular Signaling	27
The Winding Road of Calcium Channel Discovery	30
The Diversity of Native Ca2+ Channel Currents	36
	4.	Biochemical Studies of Voltage-Gated Ca2+ Channels	48
William A. Catterall
Purification and Biochemical Characterization 
of Skeletal Muscle Ca2+ Channels	48
Biochemical Properties of Other Cav1 Channels	53
Biochemical Properties of the Cav2 Family of Ca2+ Channels	54
Interactions of Ca2+ Channels with Intracellular Regulatory 
Proteins	55
	5.	Molecular Properties of Voltage-Gated Calcium Channels	61
Terrance P. Snutch, Jean Peloquin, Eleanor Mathews 
and John E. McRory
Native Voltage-Gated Ca2+ Channels	61
High Voltage-Activated Ca2+ Channels	61
Cloned Calcium Channels	66
Low Voltage-Activated (T-Type) Channels	77
Auxiliary Ca2+ Channel Subunits	79
	6.	Role of b Subunits in Voltage-Gated Calcium Channel Functions	95
Thierry Cens, Sophie Restituito, Matthieu Rousset and Pierre Charnet
Isolation, Characterization and Cloning	95
Association with Ca2+ Channels	97
Role in Channel Expression and Targeting	98
Role in Channel Properties: Activation, Inactivation 
and Facilitation	99
Role in Channel Regulation by Heterotrimeric G-Proteins	103
	7.	Distribution and Targeting Mechanisms of Voltage Activated 
Ca2+ Channels	113
Stefan Herlitze and Melanie D. Mark
Distribution of Ca2+ Channel Types Specified by Their Pore 
Forming a1 Subunit	113
Distribution of L-Type Channels	113
Distribution of P/Q-, N- and R-Type Channels	116
Cav2 in Pancreas	121
Distribution of T-Type Channels	121
Distributions of the Ancillary Subunits b, a2-d and g	122
Mechanisms of Ca2+ Channel Targeting: Transport from the ER 
to the Plasma Membrane and Specified Subcellular Structures	125
Ca2+ Channel Complex Formation in Heterologous Expression 
Systems	125
Up and Down Regulation of Ca2+ Channel Expression: 
b Subunits, g Subunits, AKAP and kir/Gem	127
Targeting of Ca2+ Channels in Skeletal and Cardiac Muscle	128
Sorting of Ca2+ Channels in Polarized Cells: A Correlation 
between Polarized Sorting in Epithelial Cells and Neurons	129
	8.	The Calcium Channel and the Transmitter Release Site	141
Elise F. Stanley and Allen W. Chan
Presynaptic Ca2+ Channel Types	142
Ca2+ Channel Localization at the Presynaptic Nerve Terminal	143
The Calcium Channel and the Triggering of Transmitter Release	144
Calcium Channel Interaction with the Proteins 
of the Transmitter Release Site	146
Modulation of Presynaptic Ca2+ Channels	148
	9.	Determinants of G Protein Inhibition of Presynaptic 
Calcium Channels	154
Aparna Nirdosh and Gerald W. Zamponi
Functional Consequences of Direct G Protein Action 
on Calcium Channels	155
Stoichiometry between G Proteins and the Calcium Channel	156
G Protein Modulation Depends on the Nature 
of the Calcium Channel Subunits	157
Gb Subunits Mediate Calcium Channel Inhibition	157
Channel and G Protein Structural Basis of G Protein Modulation	158
Interactions between G Protein and Protein Kinase C 
(PKC) Pathways	159
RGS Proteins and G Protein Modulation of Calcium Channels	160
Interactions between G Proteins and Synaptic Release Proteins	160
	10.	Phosphorylation-Dependent Regulation of Voltage-Gated 
Ca2+ Channels	168
Roger A. Bannister, Ulises Meza and Brett A. Adams
Regulation of Ca2+ Channels by Protein Kinase A (PKA)	168
Regulation of Ca2+ Channels by Protein Kinase C (PKC)	171
Regulation of Ca2+ Channels by Protein Kinase G (PKG)	172
Regulation of T-Type Ca2+ Channels by Ca2+/Calmodulin- 
Dependent Protein Kinases (CaM Kinases)	172
Regulation of Ca2+ Channels by Tyrosine Kinases	173
Regulation of Ca2+ Channels by Mitogen-Activated Protein 
(MAP) Kinases	174
Regulation of Ca2+ Channels by Lipid Kinases	175
Regulation of Ca2+ Channels by Cyclin-Dependent Kinase 
5 (Cdk5)	176
Regulation of Ca2+ Channels by Calcineurin	176
	11.	Ca2+-Dependent Modulation of Voltage-Gated Ca2+ Channels	183
Amy Lee and William A. Catterall
Feedback Regulation of VGCCs by Ca2+ in Paramecium 
and Aplysia	183
Ca2+-Dependent Modulation of Cav1.2 (L-Type) Channels	184
Molecular Determinants of Ca2+-Dependent Modulation 
in Cav1.2 Channels	185
Ca2+-Dependent Regulation of Cav2.1 (P/Q-Type) Channels	187
Differential Modulation of Cav2.1 by CaM and Neuronal 
Ca2+-Binding Proteins	190
	12.	Voltage-Dependent Inactivation of Voltage Gated 
Calcium Channels	194
Mary T. An and Gerald W. Zamponi
What Have We Learnt from Other Types of Voltage Gated 
Cation Channels?	195
a1 Subunit Structural Inactivation Determinants in High 
Voltage Activated Channels	197
Role of Ancillary Subunits in Calcium Channel Inactivation	199
Possible Molecular Mechanism of Calcium Channel Inactivation	200
	13.	Selective Permeability of Voltage-Gated Calcium Channels	205
William A. Sather
Selectivity by Ion Binding Affinity	206
A Multi-Ion Pore Confers High Flux	206
Amino Acid Residues of the Selectivity Filter	208
A Single High-Affinity Locus	211
Non-Equivalence of EEEE Locus Glutamates	212
Functional Groups that Bind Ca2+	213
Structure-Based Selectivity Models	215
	14.	The Run-Down Phenomenon of Ca2+ Channels 	219
Klaus JF Kepplinger and Christoph Romanin
Which Native Calcium Channel Types Exhibit Run-Down?	219
Prevention and Reversal of Channel Run-Down	220
The Nucleotides ATP and ADP	220
 Regulation by Phosphorylation/Dephosphorylation	222
Is Calpastatin the Regulatory Protein in the Cytoplasm?	222
Molecular Determinants of Calpastatin in the Regulation 
of Calcium Channel Activity	223
Which Subunits of the L-Type Calcium Channel Are Involved 
in the Run-Down Process?	223
Molecular Determinants for Run-Down in the a1C Subunit	223
Summary of the Molecular Mechanisms and Determinants 
of Run-Down	226
	15.	Calcium Channels As Therapeutic Targets	231
Francesco Belardetti and Sian Spacey
L-Type Channels	231
N-Type Channels	233
P/Q-Type Channels	233
T-Type Channels	235
	16.	Calcium Channelopathies	240
Nancy M. Lorenzon and Kurt G. Beam
Calcium Channelopathies of the Nervous System	240
Calcium Channelopathies of Muscle	250
	17.	The Molecular Basis of Ca2+ Antagonist Drug 
Action-Recent Developments	262
JÜrg Striessnig, Jean-Charles Hoda, Edwin Wappl 
and Alexandra Koschak
A Multisubsite Model of the Ca2+ Antagonist Drug 
Binding Domains	264
Towards a Three-Dimensional Model of the DHP 
Binding Domain	266
PAA and BTZ Binding Residues	275
Differences in DHP Sensitivity between Cav1.2 , Cav1.3 
and Cav1.4 L-Type Ca2+ Channels	275
	18.	Calcium Channel Block and Inactivation: 
Insights from Structure-Activity Studies	281
Steffen Hering, Stanislav Sokolov, Stanislav Berjukow, 
Rainer Marksteiner, Eva Margreiter and Evgeni N. Timin
Amino Acid Residues Located in the Putative Drug-Binding 
Region Affect Drug-Sensitivity and Channel Inactivation	284
Drug-Sensitivity Is Affected by Inactivation Determinants 
Located Outside the Putative Drug-Binding Region	286
b-Subunits Modulate Inactivation and Channel Inhibition	287
Inactivation Determinants and DHP Sensitivity	287
On the Role of Ca2+-Dependent Inactivation in Drug Sensitivity	290
Simulation of the Drug-Channel Interaction	290
	19.	Block of Voltage-Gated Calcium Channels by Peptide Toxins	294
Christina I. Schroeder, Richard J. Lewis and David J. Adams	
L-Type VSCC Antagonists	295
N-Type VSCC Antagonists	300
P/Q-Type VSCC Antagonists	302
R-Type VSCCC Antagonists	303
T-Type Antagonists	304
	20.	Calcium Channels in the Heart	309
StÄphanie BarrÅre-Lemaire, Matteo E. Mangoni and Joæl Nargeot
I-Cardiac Ca2+ Channels in Working Myocardial Cells	309
Cardiac Ca2+ Channels and Pacemaker Activity	315
	21.	Post-Genomic Insights into T-Type Calcium Channels 
Functions in Neurons	326
Emmanuel Bourinet, Philippe Lory, Jean Chemin, Steve Dubel, 
RÄgis Lambert, Olivier Poirot, Arnaud Monteil, Anne Feltz 
and Joel Nargeot
Contributions of Recombinant Channel Studies	327
T-Type Channels and Neurophysiology	329
	22.	Voltage-Gated Ca2+ Channels of the Vertebrate Retina: 
From the Genetics of Blindness to Encoding the Visual World	334
Melanie E.M. Kelly and Steven Barnes
Ca2+ Channels in the Graded Potential Neurons 
of the Outer Retina	336
Ca2+ Channel Subtypes in Spiking Cells of the Inner Retina	338
Differential Expression of Ca2+ Channel Subtypes during 
Retinal Development	341
	23.	Exploring the Function and Pharmacotherapeutic of Potential Voltage-Gated Ca2+ Channels with 
Gene-Knockout Models	346
JÜrg Striessnig and Alexandra Koschak
The Cav1 (L-Type) Ca2+ Channel Family	348
The Cav2 (P/Q-, N- and R-Type) Ca2+ Channel Family	353
The Cav3 (T-Type) Ca2+ Channel Family	359
Ca2+ Channel b-Subunits	362
Other Subunits	364
		Index	373

Library of Congress Subject Headings for this publication:

Calcium channels.
Calcium Channels.
Action Potentials.