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CONTENTS Preface xi List of Abbreviations xvii PART I: INVENTING NEUROSOMATIC MEDICINE: REWARDS AND SATISFACTIONS VERSUS PROBLEMS AND PITFALLS 1 Chapter 1. The Education of a Neurosomaticist 5 Chapter 2. The Office Practice of Neurosomatic Medicine 23 Bankruptcy Despite a Three-Month Waiting List Solving the Problems and Avoiding the Pitfalls Taking Care of Business Chapter 3. Lawyers and Litigation 37 Sample Pathophysiology of Post-Traumatic Fibromyalgia Mene, Mene, Tekel, Upharsin Chapter 4. Treatment Case Examples 51 Instantaneous Neural Network Reconfiguration by Pharmacologic Modulation of Afferent Cranial Nerve Input The Pathophysiology of Chronic Fatigue Syndrome and Related Neurosomatic Disorders Thyroid Function in Neurosomatic Disorders: Stimulation of Trigeminal (Nerve Activity with Thyrotropin Releasing Hormone (TRH) 62 Chapter 5. Case Reports 67 My So-Called Illness:Is It Real or All in My Head? One-Second Epiphanies My Most Unusual Case Bug of the Month Club Chapter 6. Married to the Messiah 79 PART II: SOCIETY FOR NEUROSCIENCE 87 CONFERENCE PROCEEDINGS Chapter 7. This Is . . . Los Angeles 89 Chapter 8. Neurosomatic Pearls 101 135 Eldritch Lore About Neurosomatic Therapy Chapter 9. Neurosomatic Neuroscience 145 PART III: PATHOPHYSIOLOGY AND TREATMENT 179 Chapter 10. Treatment of Neurosomatic Disorders 181 Stimulants The Corticostriatal Thalamocortical Circuit in Reverse Corticotropin-Releasing Hormone (CRH) 198 and Hypocortisolism Agmatine 202 Cholinesterase Inhibitors 202 Ascorbate (Vitamin C) 204 Amantadine 205 Adenosine 208 Baclofen 214 Gamma-Aminobutyric Acid (GABA) 216 ATP 219 Lorazepam Nasal Spray 223 Antibiotics 223 Endothelin 226 Respiratory Rhythm Regulation in Fibromyalgia Syndrome 227 231 pH and panic disorder 234 Buspirone/BuSpar 237 Thalamic Reticular Nucleus 238 The Attentional Network 240 Clonidine 243 Catecholamines 246 Norepinephrine, Dopamine, Salience, and Attention 249 Dopamine and Reward 258 Effexor (Venlafaxine) Synaptic Plasticity and Long-Term Potentiation in Neurosomatic Disorders The Postreceptor Phosphorylation Cascade 270 The Treatment of Attentional Disorders 277 Instantaneous Neural Network Reconfiguration 281 Other Aspects of Synaptic Plasticity 285 Hormonal Modulation in Neurosomatic Medicine Modulating the N-Methyl-D-Aspartate (NMDA) Receptor 289 Atypical Messengers Synaptic Fatigue Glutamate Receptors, Subunits, and Synaptic Scaling Neurotrophic Factors Conclusion Chapter 11. Modulating Glutamatergic 349 Neurotransmission Pharmacologic Modulation of Sensory Integration 352 via the Trigeminal Nerve Electroconvulsive Therapy (ECT) 354 Kinases and Phosphatases 355 The Nicotinic Cholinergic Receptor 358 Long-Term Potentiation and Depression 362 Microtubule-Associated Protein Kinases (MAPKs) 369 Gabapentin 371 Zolpidem 373 Lamotrigine 373 Pentazocine (Talwin) 374 Oxytocin 375 Opioids 377 Oxytocin, Hypothalamic Function, and Circadian Rhythms 381 384 Other Effects of Oxytocin 386 Modafinil (Provigil) 388 Ventrolateral Preoptic Nucleus (VLPO) 389 Lidocaine Gonadotropin-Releasing Hormone (GnRH) and Dysregulation of Circadian Rhythms 392 Pyrrolidines Fatigue Sleep Conclusion Conclusion. Closing the Circuit: The Role of the Nucleus 449 Accumbens in Neurosomatic Disorders Afterword 455 Appendix Diagnostic Criteria from the DSM-IV-TR Treatment Algorithm Medication List: Present and Near-Future Treatment Options for Neurosomatic Disorders CFS Symptom Checklist References
Library of Congress Subject Headings for this publication: Chronic fatigue syndrome, Fibromyalgia, Psychoneuroimmunology, Neural networks (Neurobiology)Limbic system, Psychophysiologic Disorders therapy, Neuropsychology Personal Narratives, Psychosomatic Medicine Personal Narratives