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Contents PART I AN INTRODUCTION TO IMMUNOBIOLOGY AND INNATE IMMUNITY Chapter 1 Basic Concepts in Immunology 1 Chapter 2 Innate Immunity 37 PART II THE RECOGNITION OF ANTIGEN Chapter 3 Antigen Recognition by B-cell and T-cell Receptors 103 Chapter 4 The Generation of Lymphocyte Antigen Receptors 135 Chapter 5 Antigen Presentation to T Lymphocytes 169 PART III THE DEVELOPMENT OF MATURE LYMPHOCYTE RECEPTOR REPERTOIRES Chapter 6 Signaling Through Immune System Receptors 203 Chapter 7 The Development and Survival of Lymphocytes 241 PART IV THE ADAPTIVE IMMUNE RESPONSE Chapter 8 T Cell-Mediated Immunity 319 Chapter 9 The Humoral Immune Response 367 Chapter 10 Adaptive Immunity to Infection 409 PART V THE IMMUNE SYSTEM IN HEALTH AND DISEASE Chapter 11 Failures of Host Defense Mechanisms 461 Chapter 12 Allergy and Hypersensitivity 517 Chapter 13 Autoimmunity and Transplantation 557 Chapter 14 Manipulation of the Immune Response 613 Chapter 15 Evolution of the Innate Immune System 663 Appendix I Immunologists' Toolbox 681 Appendix II CD Antigens 729 Appendix III Cytokines and their Receptors 745 Appendix IV Chemokines and their Receptors 748 Appendix V Immunological Constants 749 Biographies 750 Glossary 751 Index 799 xiii
Library of Congress Subject Headings for this publication: Immunology, Immunity