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Contents Preface v Contributors ix 1 Mammalian Cell Death Pathways: Intrinsic and Extrinsic xxx E. Robert McDonald, III and Wafik S. El-Deiry 2 Resistance to Apoptosis in Cancer Therapy xxx David J. McConkey 3 Structures of TNF Receptors and Their Interactions With Ligands xxx Sarah G. Hymowitz and Abraham M. de Vos 4 Death Receptor Signaling in Embryonic Ectodermal Development xxx Preet M. Chaudhary 5 Adaptor Proteins in Death Receptor Signaling xxx Nien-Jung Chen and Wen-Chen Yeh 6 Caspase Activation by the Extrinsic Pathway xxx Xiaolu Yang 7 Death Signaling and Therapeutic Applications of TRAIL xxx Mi-Hyang Kim and Dai-Wu Seol 8 Death Receptor Mutations xxx Sug Hyung Lee, Nam Jin Yoo, and Jung Young Lee 9 Regulation of Death Receptors xxx Udo Kontny and Heinrich Kovar 10 Regulation of TRAIL Receptor Expression in Human Melanoma xxx Peter Hersey, Si Yi Zhang, and Xu Dong Zhang 11 Regulation of Death Receptors by Synthetic Retinoids xxx Shi-Yong Sun 12 Role of p53 in Regulation of Death Receptors xxx Rishu Takimoto 13 Pro-Apoptotic Gene Silencing Via Methylation in Human Tumors xxx Tanya Tekautz, Tal Teitz, Jill M. Lahti, and Vincent J. Kidd 14 Regulation of Death Receptor-Induced Apoptosis by NF-_B and Interferon Signaling Pathways: Implications for Cancer Therapy xxx Rajani Ravi and Atul Bedi 15 TRAIL in Cancer Therapy xxx Mahaveer Swaroop Bhojani, Brian D. Ross, and Alnawaz Rehemtulla 16 Expression and Regulation of Death Receptors in Multiple Myeloma and Prostate Carcinoma xxx Subrata Ray, John G. Hissong, Marcela Oancea, and Alex Almasan 17 Regulation of TRAIL-Induced Apoptosis by Transcriptional Factors xxx Rüdiger Göke and Youhai H. Chen 18 Sensitizing Tumor Cells by Targeting Death Receptor Signaling Inhibitors xxx Christina Voelkel-Johnson 19 Ceramide, Ceramidase, and FasL Gene Therapy in Prostate Cancer xxx James S. Norris, David H. Holman, Marc L. Hyer, Alicja Bielawska, Ahmed El-Zawahry, Charles Chalfant, Charles Landen, Stephen Tomlinson, Jian-Yun Dong, Lina M. Obeid and Yusuf Hannun 20 Gene Therapy Targeting Receptor-Mediated Cell Death to Cancers xxx Lidong Zhang and Binglian Fang 21 Combination of Chemotherapy and Death Ligands in Cancer Therapy xxx Simone Fulda and Klaus-Michael Debatin Index xxx
Library of Congress Subject Headings for this publication: Apoptosis, Cell receptors, Cancer Molecular aspects, Cellular signal transduction, Neoplasms immunology, Neoplasms therapy, Cell Death immunology, Gene Therapy methods, Receptors, Tumor Necrosis Factor