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CONTENTS Preface viii Acknowledgments xi Introduction xii 1 Stem Cells Are Not All Equal The Mammalian Embryo Embryonic Stem Cells Adult Stem Cells Stem Cells in Culture Stem Cell Markers 2 Human Stem Cells Collecting Human Embryonic Stem Cells Fate of the Donor Embryo Directed Differentiation Growth Factors Future Prospects for Adult Stem Cells 3 Medical Applications Leukemia Immune Deficiencies Diabetes Liver Disease Cardiovascular Disease Neurological Disorders Organ Factories 4 Commercialization of Human Stem Cells The Stock Market Astrom Biosciences, Inc. StemCells, Inc. Geron Corporation 5 Reality Check The Problem of Immune Rejection Spontaneous In Vitro Differentiation Wandering Stem Cells Stem Cell Cancer Induction Growing Organs From Cultured Stem Cells 6 Ethical Issues Justice and Beneficence High-Tech Cannibalism On Becoming Human The Early Embryo 7 Legal Issues The United Kingdom The European Union The United States 8 Resource Center Eucaryote Cell Primer Recombinant DNA Primer Gene Therapy Primer The Belmont Report The Gelsinger Investigation Clinical Trials APPENDIXES Glossary Further Reading Websites Index
Library of Congress Subject Headings for this publication: Stem cells Research, Stem cells Research Moral and ethical aspects