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Foreword Cathy Wilfert List of contributors Preface Introduction Part I. Scientific Basis of Pediatric HIV Care: 1. Normal development and physiology of the immune system Sherlyn Smith and Ann J. Melvin 2. HIV basic virology for clinicians Steven L. Zeichner 3. Immunology of pediatric HIV disease/infection Elizabeth J. McFarland 4. Clinical virology of pediatric HIV disease/infection Paul Palumbo 5. Natural history of pediatric HIV disease/infection Grace M. Aldrovandi 6. Epidemiology of pediatric HIV disease/infection Mary Lou Lindegren Part II. General Issues in the Care of Pediatric HIV Patients: 7. Diagnosis of HIV infection Paul Krogstad 8. Prevention of mother-to-child/vertical transmission of HIV Jennifer S. Read 9. Routine pediatric care Elaine Abrams and Lisa-Gaye Robinson 10. Immunizations Rachel Y. Moon 11. Prophylaxis for opportunistic infections Russell B. Van Dyke 12. Emergency evaluation and care James M. Callahan 13. Adherence to therapy in pediatric HIV disease John Farley 14. Adolescents and HIV Bret R. Rudy 15. Gynecology of the HIV-infected adolescent Ligia Peralta and Sandra Cely 16. Growth, nutrition and metabolism Caroline J. Chantry and Jack Moye Jr 17. Neurodevelopmental/neurobehavioral function and assessment of children with HIV-1 infection Pamela L. Wolters and Pim Brouwers Part III. Antiretroviral Therapy: 18. Antiretroviral therapy Ross McKinney Jr 19. Antiretroviral drug interactions Thomas N. Kakuda and Courtney V. Fletcher 20. Metabolic complications of antiretroviral therapy Carol J. Worrell 21. Assessment and management of resistance to antiretroviral therapy Frank Maldarelli 22. Initiating and changing antiviral therapy Lynne M. Mofenson and Leslie K. Serchuck 23. Therapeutic drug monitoring Stephen C. Piscitelli 24. HIV post-exposure prophylaxis for pediatric patients Kenneth L. Dominguez Part IV. Clinical Manifestations of HIV Infection in Children: 25. Dermatological problems in HIV-infected children Andrew Blauvelt 26. Neurologic problems Lucy Civitello 27. Ophthalmologic problems in the HIV-infected child Howard F. Fine, Susan S. Lee and Michael R. Robinson 28. Oral health and dental problems (in the HIV-infected child) Jane C. Atkinson 29. Otitis media and sinusitis Ellen R. Wald and Barry Dashefsky 30. Cardiac problems Gul H. Dadlani and Steven E. Lipshultz 31. Pulmonary problems Lauren V. Wood 32. Hematologic problems William C. Owen and Eric J. Werner 33. Gastrointestinal disorders Harland S. Winter and Jack Moye 34 Renal disease in pediatric HIV infection Somsak Tanawattanacharoen and Jeffrey B. Kopp 35. Endocrinologic problems Daina Dreimane and Mitchell E. Geffner 36. Neoplastic disease in pediatric HIV infection Richard F. Little Part V. Infectious Problems in Pediatric HIV Disease: 37. Typical bacterial infections Shirley Jankelevich 38. Tuberculosis Rohan Hazra 39. Atypical mycobacteria Robert N. Husson 40 Fungal infections Corina E. Gonzalez 41. Herpesvirus infections Richard M. Rutstein and Stuart E. Starr 42. Pneumocystis carinii (PCP) Leslie K. Serchuck Part VI. Medical Social and Legal Issues: 43. Clinical trials for HIV infected children James McNamara 44 Medical issues related to the care for HIV-infected children in the home, day care, school, and community Stephen J. Chanock 45. Contact with social service agencies Sandra Y. Lewis and Heidi J. Haiken 46. Disclosure Lori S. Wiener 47. Bereavement Lori S. Wiener 48. Legal issues for HIV-infected children Carolyn McAllaster Appendices Formulary/drug ready reference Paul Jarosinki NIH-sponsored clinical trials for pediatric HIV disease James McNamara Online resources Leslie K. Serchuck Legal appendix Carolyn McAllaster Index.