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Introduction Part I. General Methods: 1. The question 2. Finding relevant studies 3. Appraising and selecting studies 4. Summarising and synthesising the studies 5. Applicability: returning to the question Part II. Question-Specific Methods: 6. Interventions 7. Frequency and rate 8. Diagnostic tests 9. Aetiology and risk factors 10. Prediction: prognosis and risk Appendix A. Literature searching methods Appendix B. Software for meta-analysis Glossary Acronyms and abbreviations References Index.