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1. Preface and overview 2. Drug prohibition: American style 3. The debate 4. Philosophical underpinnings 5. How does prohibition affect drug use? 6. How does prohibition affect drug harms? 7. Other vices: prostitution and gambling 8. Other substances: alcohol and cigarettes 9. US experience with legal cocaine and heroin 10. Learning from European experiences 11. Cannabis policies in the Netherlands 12. Harm reduction in Europe 13. Summary of the evidence and a framework for assessment 14. Projecting the consequences of alternative regimes 15. Obstacles to moving beyond the drug war.