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Table of contents for Biology of menopause / Francis L. Bellino, editor.


Contents

Preface        vii
Contributors   xiii

     1. New Understanding of the Complexity of the
     Menopause and Challenges for the Future           1
     PHYLLIS M. WISE

     Part I. Hypothalamic-Pituitary-Ovarian Axis
                During Reproductive Aging

     2. Luteinizing Hormone Releasing Hormone (LHRH)
     Neuronal Function in Middle-Aged Female Rats           11
     BEVERLY S. RUBIN AND MERCEDES JIMENEZ-LINAN

     3. Reproductive Aging and the Human Hypothalamus       24
     NAOMI E. RANCE, TY W. ABEL, AND STEVE C. DANZER

     4. Alterations in the Pattern of Gonadotropin Secretion
     During the Menopausal Transition        35
     DENNIS W. MATT, MARIE C. KERBESHIAN, STEVEN M. PINCUS,
     JOHANNES D. VELDHUIS, AND WILLIAM S. EVANS

     5. Clinical and Scientific Significance of Perimenopausal
     Changes in Pituitary and Ovarian Hormone Secretion          45
     GERSON WEISS

     6. Follicular Depletion and the Menopausal Transition       54
     ANNE NEWMAN HIRSHFIELD AND JODI ANNE FLAWS
          
     7. Ovarian Follicle Recruitment and Secretory Capacity
     in Women of Advanced Reproductive Age   66
     NANCY A. KLEIN, DAVID E. BATTAGLIA, AND MICHAEL R. SOULES

     8. New Strategies in Studying Ovarian Aging  
     KUTLUK OKTAY, GUVENC KARLIKAYA, AND AYKUT BAYRAKCEKEN

     Part II.  Effects of Reproductive Aging
          on Nonreproductive Tissues

     9. Novel Mechanisms of Estrogen Action
     in the Developing Brain ........................
     C. DOMINIQUE TORAN-ALLERAND

     10. Neuroprotective Effects of Estrogens     103
     JAMES W. SIMPKINS, PATTIE S. GREEN, KELLY E. GRIDLEY,
     JIONG SHI, AND EILEEN K. MONCK

     11. Cognitive Changes and Aging: Is Estrogen a Factor?
     BARBARA B. SHERWIN

     12. Age-Related Changes and Hormonal Regulation
     of Mesenchymal Stromal Stem Cells from Human
     Vertebral Bone Marrow    121
     GIANLUCA D'IPPOLITO, PAUL C. SCHILLER, CAMILLO RICoRDI,
     BERNARD A. RODS, AND GUY A. HOWARD

     13. Cellular and Molecular Mechanisms of
     Postmenopausal Osteoporosis   134
     STAVROS C. MANOLAGAS

     14. Changes in Cardiovascular Risk Factors During the
     Peri- and Postmenopausal Years     147
     KAREN A. MATTHEWS, LEWIS H. KULLER,
     AND KIM SUTTON-TYRRELL

     15. Estrogen and the Vascular Injury Response     159
     C. ROGER WHITE AND SUZANNE OPARIL

     16. Effects of Mammalian and Plant Estrogens on
     Lipoprotein Metabolism and Coronary Heart Disease      171
     JANICE D. WAGNER, LI ZHANG, KATHRYN A. GREAVES,
     AND DAWN C. SCHWENKE

     17. Potential Cardioprotective Effects of Estrogen
     Involving Ion Channels, Endothelium, and
     Coronary Artery Reactivity         181
     JOSEPH E. BRAYDEN, ADRIAN BONEV, KAREN LOUNSBURY,
     HARM KNOT, GEORGE C. WELLMAN, AND MARK T. NELSON

     18. Role of the Membrane Estrogen Receptor
     in Vascular Cell Physiology        189
     ELLIS R. LEVIN

     19. Role of Nitric Oxide in the Antiatherosclerotic
     Effect of 17B-Estradiol       193
     KATALIN KAUSER AND GABOR M. RUBANYI


     20. Biological and Psychosocial Factors Affecting
     Sexual Functioning During the Menopausal Transition         21 1
     LORRAINE DENNERSTEIN, PHILIPPE LEHERT, HENRY BURGER,
     AND EMMA DUDLEY

     Part III. New Methods and Emerging Areas

     21. Transgenic Models to Study Reproduction,
     Oncogenesis, and Development       225
     JULIA A. ELVIN AND MARTIN M. MATZUK

     22. Studying the Genetics of Complex But Common
     Human Diseases Using Mice          238
     NOBUYO MAEDA AND OLIVER SMITHIES

     23. The Classic Steroid Hormone Receptors and ER(3,
     the Novel Estrogen Receptor .      247
     R. REX DENTON, SAMIR K. GHOSH, ROLAND BARON.
     AND ANURADHA RAY

     24. Estrogen Receptor Alpha versus Beta: New Estrogen
     Responsive Tissues and New Potentials for HRT          259
     ISTVAN MERCHENTHALER AND PAUL J. SHUGHRUE

     25. Putting the Menopause into Perspective: Lessons
     Learned from the Biology of Menopause        273
     FREDERICK NAFTOLIN

     Author Index   279

     Subject Index  281