Table of contents for BCL-2 protein family : essential regulators of cell death / edited by Claudio Hetz.

Bibliographic record and links to related information available from the Library of Congress catalog

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1. Homeostatic Functions of BCL‑2 Proteins Beyond Apoptosis Nika N. Danial, Alfredo Gimenez‑Cassina and Daniel Tondera Abstract Mitochondrial Energy Metabolism Autophagy Protein Quality Control and the Unfolded Protein Response Physiologic Roles for BCL‑2 Family Proteins in Cell Cycle Checkpoints, Differentiation and DNA Damage Response Conclusion 2. Alternative Functions of the BCL‑2 Protein Family at the Endoplasmic Reticulum Diego Rojas‑Rivera, Benjamin Caballero, Sebastian Zamorano, Fernanda Lisbona and Claudio Hetz Abstract Introduction The BCL‑2 Protein Family and the Unfolded Protein Response Chronic ER Stress and BH3‑Only Proteins The BCL‑2 Protein Family and the Calcium Rheostat Autophagy and the BCL‑2 Protein Family of Proteins Conclusion 3. BH3‑Only Proteins and Their Efects on Cancer Thanh‑Trang Vo and Anthony Letai Abstract Introduction Categories of BCL‑2 Family Proteins and Their Apoptotic Functions Regulation of Various BH3‑Only Proteins and Cell Stress Sensing BH3‑Only Proteins and Cancer Development BH3‑Only Proteins and Chemotherapy Response and Resistance BH3‑only Mimetic Drugs Conclusion 4. Endoplasmic Reticulum Stress and BCL‑2 Family Members Ross T. Weston and Hamsa Puthalakath Abstract Introduction UPR: The Good and the Evil Side UPR and BCL‑2 Family Members Autophagy, UPR and BCL‑2 Family Members Conclusion 5. Targeting Survival Pathways in Lymphoma Luca Paoluzzi and Owen A. O’Connor BCL‑2 Family of Proteins and Cell Death Abstract Introduction Pharmacologic Modulation of BCL‑2 Proteins and Apoptosis BCL‑2 Proteins and Non‑Apoptotic Cell Death Conclusion 6. The Interplay between BCL‑2 Family Proteins and Mitochondrial Morphology in the Regulation of Apoptosis Maria Eugenia Soriano and Luca Scorrano Abstract Introduction BCL‑2 Family Mitochondrial Shape and Apoptosis Conclusion 7. Noncanonical Functions of BCL‑2 Proteins in the Nervous System Heather M. Lamb and J. Marie Hardwick Abstract Introduction Extending the Traditional View of BCL‑2 Family Proteins Challenging the Traditional BCL‑2 Family Model BCL‑2 Family Proteins in the Nervous System When Anti‑Death BCL‑2 Proteins Become Pro‑Death When Pro‑Death BCL‑2 Proteins Protect Neurons Protection Predicts New Functions with a Seizure BCL‑2 Family Proteins Regulate Synaptic Activity Mitochondrial Dynamics in Neuronal Function Conclusion 8. Mitochondria on Guard: Role of Mitochondrial Fusion and Fission in the Regulation of Apoptosis Mariusz Karbowski Abstract Introduction Regulation of Mitochondrial Fusion and Fission Mitochondrial Network Dynamics and Cell Homeostasis Role of Mitochondrial Dynamics in Cell Death Mechanism of the OM Permeabilization: A Vital Role for Mitochondrial Fusion and Fission? Emerging Evidence for the Role of BCL‑2 Family Proteins in the Regulation of Mitochondrial Network Dynamics in Healthy Cells Conclusion Index

Library of Congress subject headings for this publication:
Tumor proteins.
Proto-Oncogene Proteins c-bcl-2 -- metabolism.
Proto-Oncogene Proteins c-bcl-2 -- physiology.
Apoptosis -- physiology.
Neoplasms -- metabolism.
Neoplasms -- pathology.