Table of contents for Essential guide to blood coagulation / edited by Jovan P. Antovic, Margareta Blomback.


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1. PREFACE
GENERAL HEMOSTASIS
2. SCHEMATIC PRESENTATION OF THE HEMOSTATIC SYSTEM
3. PROPOSALS FOR INVESTIGATION AND SAMPLING INSTRUCTIONS
Increased bleeding tendency
Screening analyses
Venous thromboembolism
Arterial thromboembolism
Preanalytical consideration to note in the patient prior to sampling
Resting before sampling, position at sampling, sampling occasion etc
4. LABORATORY INVESTIGATION
Nomenclature
Reference intervals for laboratory investigations
Screening analyses
Pt-Bleeding time
B/CB-PLT (platelet particle concentrations equals number of platelets)
P-APT-time (activated partial thromboplastin time)
P-B/CB-Prothrombin complex
P-B/CB-Pt (INR)
Special analyses
Coagulation factors
Anticoagulants
Natural coagulation inhibitors
Platelet function
Fibrinolysis
Markers for coagulant activation (Hyper-coagulation markers)
DNA analyses
DNA analysis of hemophilia A and B
DNA analysis in thrombotic disorders
Useful components in research studies
Other non-hemostatic variables of importance
5. IMAGING DIAGNOSTIC PROCEDURES
BLEEDING DISORDERS
6. HEREDITARY BLEEDING DISORDERS
SEVERE FORMS
Factor concentrates used in treatment of hemophilia A, B and VWD
Treatment strategy in severe forms of hemophilia and VWD
Painkilling drugs allowed in hemophilia and VWD
Side effects above all at treatment of severe forms of hereditary bleeding disorders
Treatment principles for different forms of bleeding disorders (severe, moderate and milder forms of hemostatic defects)
Delivery
Treatment with tranexamic acid
Severe platelet function defects e.g. thrombastenia Glanzmann
MILD HEMOSTATIC DEFECTS
General remarks
Treatment in general
Treatment with desmopressin (Octostim)
Blood sampling in hemophilia patients
Bleeding risk charts (suggestion for)
7. SERIOUS NON-HEREDITARY BLEEDINGS
Introduction
Massive bleedings
Transfusion coagulopathy
Treatment
Complicating factors
8. INVESTIGATIONS OF INCREASED BLEEDING TENDENCY
Background
Diagnosis
Suggested questions for bleeding history
Laboratory tests (see also above)
Explanations for pathological screening analyses and further actions
Prolonged bleeding time
Thrombocytopenia
Prolonged APT-time
Elevated PT (INR)
Investigations of bleeding tendency; practical aspects
THROMBOEMBOLIC DISORDERS
9. VENOUS THROMBOSIS AND PULMONARY EMBOLISM
Introduction
Diagnosis of venous thrombosis
Tools for confirming or discarding a clinical suspicion of a venous thrombosis.
Superficial thrombophlebitis
Diagnosis of pulmonary embolism
Tools for confirming or excluding clinical suspicion of pulmonary embolism
NON PHARMACOLOGICAL TREATMENT OF DVT AND PE
DRUG TREATMENT IN DVT AND PE
Heparin (UFH) and low molecular weigh heparin (LMH)
Treatment of superficial thrombophlebitis
Bleeding complications in treatment with UFH and LMH
Thrombolytical treatment
Thrombolytic drugs
Bleeding complications in thrombolytic treatment
Secondary prophylaxis against DVT and PE with AVK drugs
Practical advice: patients treated with AVK drugs
Elective adjustment of PT(INR) prior to risk situations e.g. tooth extraction, surgery etc
Bleeding during treatment with UFH/LMH, thrombin inhibitors and pentasaccarides
PRIMARY PROPHYLAXIS AGAINST DVT AND PE
10. ARTERIAL THROMBOEMBOLISM
Ischemic heart disease
Unstable angina pectoris/non ST-elevation myocardial infarction (NONSTEMI)
ST-elevating myocardial infarction (STEMI)
Cardiac arrhythmias (atrial fibrillation)
Peripheral artery diseases
Surgery on peripheral arteries
Cerebral ischemia
Thrombolysis in stroke
Recurrent TIA
11. INVESTIGATIONS OF THROMBOEMBOLIC TENDENCY
SPECIAL HEMOSTASIS
12. HEMOSTATIC DEFECTS IN OBSTETRICS AND GYNECOLOGY
Thrombosis during pregnancy
Treatment in acute DVT/PE during pregnancy and at partus
Breast feeding
Special cases
Treatment of women with mechanical heart valve prothesis
Thromboprophylaxis during pregnancy, partus and post partum
Dosage of LM-heparin (LMH) in thromboprophylaxis
Thromboprophylaxis at Caesarean section
Obstetric epidural/spinal analgesia (anaesthesia)
Complications during pregnancy
Thromboprophylaxis in legal and spontaneous abortions
Thromboprophylaxis in gynecological surgery
Oral contraceptives, hormone substitution and surgery
Investigation prior to artificial insemination
Investigation prior to oral contraceptives, advice concerning oral contraceptives
Investigation prior to post-climacteric substitution treatment (HRT=hormone replacement therapy)
Investigation in repeated miscarriages
Investigation in menorrhagia
13.HEMOSTATIC DEFECTS IN CHILDREN
Bleedings
Introduction
Bleeding in newborns
Coagulation factor deficiencies
Acquired bleeding tendency
Thromboembolic disease in children
Introduction
Venous thrombosis
Sinus thrombosis
Arterial thrombosis
Stroke
14. EMERGENCY CONDITIONS ASSOCIATED WITH ACTIVATION OF COAGULATION
Disseminated intravascular coagulation (DIC)
Definition
Pathophysiology
Clinical picture
Laboratory diagnosis
Treatment
Coagulatopathy in septic shock
Heparin-induced thrombocytopenia
Thrombotic microangiopathies (TTP and HUS)
List of components and analyses


Library of Congress subject headings for this publication:
Blood coagulation disorders.
Blood Coagulation.
Blood Coagulation Disorders.
Embolism -- physiopathology.
Thrombosis -- physiopathology.