Publisher description for Immunotoxicology strategies for pharmaceutical safety assessment / [edited by] Danuta J. Herzyk, Jeanine L. Bussiere.


Bibliographic record and links to related information available from the Library of Congress catalog


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This core reference explains current strategies for immunotoxicology pharmaceutical safety assessments, which can reduce drug candidate attrition and streamline the development process. This guide thoroughly covers the testing needed to detect and characterize low-level immunotoxic hazards: 1) immunochemistry to address immunogenicity of biopharmaceuticals; 2) molecular immunology to evaluate immune dysregulation at the subcellular level; and 3) in vivo models of immune disorders to characterize potential impairment of host defense to infections, tumors, and autoimmune diseases. This is a key resource for practicing toxicologists and scientists involved in drug development or regulation.


Library of Congress subject headings for this publication:
Immunotoxicology.
Immune system -- Effect of drugs on.
Toxicity testing.
Drugs -- Toxicology.
Drug Toxicity -- immunology.
Drug Design.
Drug Evaluation -- methods.
Immune System -- drug effects.
Immunotoxins -- adverse effects.
Risk Assessment.