Publisher description for Death receptors in cancer therapy / edited by Wafik S. El-Deiry.


Bibliographic record and links to related information available from the Library of Congress catalog


Information from electronic data provided by the publisher. May be incomplete or contain other coding.


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An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.


Library of Congress subject headings for this publication:
Apoptosis.
Cell receptors.
Cancer -- Molecular aspects.
Cellular signal transduction.
Neoplasms -- immunology.
Neoplasms -- therapy.
Cell Death -- immunology.
Gene Therapy -- methods.
Receptors, Tumor Necrosis Factor.