Table of contents for The cancer clock / [edited by] Sotiris Missailidis.


Bibliographic record and links to related information available from the Library of Congress catalog


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Counter
Introduction

1. Socioeconomic and molecular basis of cancer (Prof. David E.G. Shuker)
1.1 Introduction
1.1.1 Time
1.1.2 Place
1.2 Diet and cancer
1.2.1 Man-made contaminants of food
1.2.2 Natural contaminants of food
1.2.3 Assessing the risk
1.3 Alcohol and cancer
1.4 Tobacco and cancer
1.5 Conclusions
1.6 Self-assessment questions
1.7 Further reading and resources

2. Metals and Cancer (Prof. J. Anastasopoulou and Dr A. Dovas)
2.1 Introduction
2.2 Role of metals
2.2.1 Metal–DNA interactions
2.2.2 Uranium–nucleotide interactions
2.2.3 Toxicity and biological roles of copper
2.2.4 Formation of free radicals by metal ions
2.3 Radiolysis
2.4 Free radicals
2.4.1 Biomolecular targets of free radicals
2.4.2 Free radicals and metal ions in cancer
2.5 Conclusions
2.6 Self-assessment questions
2.7 Further reading and resources

3.Genetics and cancer (Dr S. Missailidis)
3.1 Introduction
3.2 Genes and cancer
3.3 Genomics
3.3.1 Comparative genomics
3.3.2 Oncogenomics
3.3.3 Nutrigenomics
3.4 Summary
3.5 Self-assessment questions
3.6 Further reading and resources

4. Infection and cancer (Dr T. Aebischer and Dr. Thomas Rudel)
4.1 Viral infection as a cause of cancer
4.1.1 Introduction
4.1.2 Principles of oncogenic transformation by virus infection
4.1.3 Human pathogenic viruses causing cancer
4.2 Bacterial infection as a cause of cancer
4.2.1 Introduction
4.2.2 Bacterial infection causing malignancies: examples and evidence

4.2.3 Common molecular machines linked to pathogenesis

4.2.4 Other bacterial effects potentially contributing to cancer
4.2.5 Anti-infection strategies to prevent infection related cancer
4.3 Summary
4.4 Self-assessment questions_
4.5 Further reading and resources

5. Inflammation and cancer (Dr Nigel Courtenay-Luck)
5.1 Introduction
5.1.1 Acute inflammation
5.1.2 Chronic inflammation
5.2 Acute inflammation
5.2.1 Mediators of acute inflammation
5.3 Chronic inflammation
5.4 Drugs used in inflammation and cancer
5.4.1 COX-2 inhibitors
5.4.2 Antihypertensive drugs
5.5 Evidence for a molecular link between inflammation and cancer
5.6 Clinical relationship between inflammatory disease and cancer
5.6.1 Inflammatory bowel disease
5.6.2 Prostate cancer
5.7 Discussion
5.8 Self-assessment questions
5.9 Further reading and resources

6. Cancer diagnosis (Prof. K. Charalabopoulos and Prof. A. Batistatou)
6.1 Blood tests for tumour markers
6.1.1 Established and novel tumour markers in serum
6.1.2 Various types of tumour markers in use
6.2 Urine tests for tumour markers
6.3 Smear tests and their association with tumour development
6.4 Histopathology
6.4.1 Benign tumours
6.4.2 Malignant tumours
6.4.3 Features of cancerous cells
6.4.4 Immunohistochemistry
6.5 Summary
6.6 Self-assessment questions
6.7 Further reading and resources


7. Tumour imaging (Prof. Alan Perkins)
7.1 Introduction
7.2 X-ray imaging
7.2.1 Mammography
7.2.2 X-ray CT
7.3 Nuclear medicine
7.3.1 The gamma camera
7.3.2 Positron emission tomography
7.4.3 Intra-operative probes
7.4 Ultrasound imaging
7.4.1 Colour Doppler imaging
7.5 Magnetic resonance imaging
7.6 Radiation therapy
7.6.1 Therapeutic nuclear medicine
7.6.2 Brachytherapy
7.6.3 External beam radiotherapy
7.7 Conclusions
7.8 Acknowledgement
7.9 Self-assessment questions
7.10 Further reading and resources
8.Surgery (Bassam Zeina)
8.1 Introduction
8.11 What Is surgery?
8.12 What is cancer surgery?
8.13 Who deals with cancer surgery?
8.14 Aims of cancer surgery
8.2 Cancer surgery as a diagnostic_ procedure
8.3 Cancer surgery as a preventive measure against cancer
8.4 Cancer surgery as treatment or part of the treatment
8.4.1 Surgery as a primary treatment
8.4.2 Cancer staging
8.4.3 Debulking (cytoreductive) surgery
8.4.4 Palliative surgery (relieving symptoms or side effects)
8.5 Classic/traditional cancer surgery
8.6 Other common techniques in cancer surgery
8.6.1 Electrosurgery
8.6.2 Cryosurgery
8.6.3 Laser surgery and photodynamic therapy (PDT)
8.6.4 Mohs’ micrographic surgery
8.6.5 Laparoscopic surgery
8.6.6 Image-guided surgery
8.7 Before and after cancer surgery
8.7.1 Preparation for the surgery
8.7.2 Anaesthesia
8.7.3 Recovery
8.8 Cancer surgery associated risks
8.9Informed consent
8.10 Summary
8.11 Self-assessment questions
8.12 Further reading and resources

9. Anticancer therapeutics (Dr Teni Boulicas et al.)
9.1 Introduction
9.1.1 Problems in cancer
9.1.2 Cancer treatments
9.1.3 Classification of chemotherapy drugs
9.2 Platinum drugs
9.2.1 Cisplatin
9.2.2 Lipoplatin
9.2.3 Carboplatin
9.2.4 Oxaliplatin
9.2.5 New platinum compounds
9.3 Antimicrotubule agents
9.3.1 Taxanes
9.3.2 Vinca alkaloids
9.4 Antimetabolites
9.4.1 5-Fluorouracil
9.4.2 Xeloda (capecitabine)
9.4.3 Gemcitibine
9.5 Antitumour antibiotics
9.5.1 Actinomycin D
9.5.2 Mitomycin C
9.5.3 Bleomycin
9.5.4 Anthracyclines
9.5.5 Podofylotoxines
9.5.6 Camptothecines
9.6 Alkylating agents
9.6.1 Cyclophosphamide
9.6.2 Ifosfamide
9.7 Other antitumour agents
9.7.1 Tamoxifen
9.8 Combination chemotherapy
9.9 Growth factor signalling
9.9.1 Tarceva
9.9.2 Other signal transduction inhibitors
9.10 Cell cycling and cancer
9.11 Apoptosis and cancer
9.12 Angiogenesis and cancer
9.13 Cancer immunotherapy
9.13.1 Monoclonal antibodies as anticancer drugs
9.13.2 Cancer vaccines
9.14 Gene therapy
9.15 RNAi (siRNA)
9.16 Antisense_________
9.17 Viruses able to kill cancer cells
9.18 Aptamers
9.19 Summary
9.20 Self-assessment questions
9.21 Further reading and resources
_______________________
10. Palliative care in oncology (Prof. M. Bernardo-Filho et al.)
10.1 Palliative care: concept and brief history
10.2 Cancer epidemiology and palliative care situation around the world
10.3 Bioethics and palliative care
10.4 Basic principles in palliative care
10.5 Symptoms control in oncology palliative care
10.5.1 Pain relief in cancer
10.6 Advanced cancer: Related symptoms and interventions
10.6.1 Fatigue
10.6.2 Dyspnoea
10.6.3 Cognitive aspects
10.6.4 Constipation
10.6.5 Anorexia
10.6.6 Nausea and vomiting
10.6.7 Ulcerated lesions
10.7 Psycho-spiritual aspects in oncology palliative care
10.8 Conclusions
10.9 Self-assessment questions
10.10 Further reading and resources

11. Physiotherapy in cancer patients (Prof. T. Nobrega et al.)
11.1 Physiotherapy and oncology
11.2 The importance of the studies on cancer and physiotherapy
11.3 Possible Interventions of the physiotherapist in specific types of cancer
11.3.1 Breast cancer
11.3.2 Gynaecological cancers
11.3.3 Prostate cancer
11.3.4 Head and neck cancers
11.3.5 Melanoma and non-melanoma skin cancers
11.3.6 Colorectal cancer
11.3.7 Lung cancer
11.3.8 Non-Hodgkin’s lymphoma
11.4 Physiotherapy, exercise prescription and technological advances
11.5 Physiotherapy and palliative care in oncology
11.6 Physiotherapy in the actions, community expectations and quality of life in oncology
11.7 Self-assessment questions
11.8 Further reading and resources

12. Psychosocial oncology (Dr I. McCubbin and Prof. C. White)
12.1 Introduction
12.2 Cancer and psychological distress
12.3 Assessment process
12.2.1 Integrating sources of information
12.2.2 Using diaries for assessment
12.4 Formulation
12.5Psychological interventions
12.5.1 Processes targeted in psychological interventions
12.5.2 Specific treatment modalities
12.6 Does psychological intervention influence survival?
12.7 Summary
12.8 Self-assessment questions
12.9 Further reading and resources





Library of Congress subject headings for this publication:
Cancer.
Oncology.
Neoplasms.