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This groundbreaking work offers a comprehensive view of the different components of metabolic stress and its association -- and that of obesity -- with oxidative stress and inflammation It reports cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro inflammatory processes in obesity and type 2 diabetes. It also addresses the molecular mechanisms inherent in the progression of metabolic stress, and considers phenotypic perspectives, as well as dietary factors and micronutrients. The book encourages evidence-based nutritional and pharmacological therapies to attenuate the impact of obesity-induced insulin resistance and ensuing metabolic syndrome.