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Incorporating recent advances in molecular biology and further developing the concepts of cellular and molecular mechanisms, this second edition features new chapters on types of toxic responses, novel mechanisms derived from systems toxicology, and disruption of cellular signal transduction by xenobiotics. The chapter on the disruption of mitochondrial function by xenobiotics has been expanded to cover mitochondrial outer membrane permeabilization and selective depletion of mitochondrial DNA. The book contains new examples and illustrations to supplement material. Additional topics include blood testis barrier, ER stress response, and retinoic acid receptor.