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This handbook on the statistical issues of genomics covers current methods and the tried-and-true classical approaches, providing a complete picture of genome statistics. It contains much basic information on the use of statistics in genomics, including how to determine a sample size and carry out a hypothesis test. This volume is different from other statistics books on genetics in that it contains a mixture of discrete and continuous variables and larger amounts of data, describes the need for bioinformatics, and is computationally intensive. It also features software available on the Internet.