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This is the first book that evaluates the application of multimetric indices and biological indicators as endpoints in order to determine the relevancy of monitoring and evaluating programs in North America so that patterns in biological responses can be assessed. It includes state-of-the-art diagnostic tools and examines patterns relating to point or non-point source impacts. From the conceptual framework to the case studies, this book will help readers better diagnose the stressors to biological communities and, thus, take actions to protect and restore water resources.