Publisher description for Neurodegenerative diseases and metal ions / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel.


Bibliographic record and links to related information available from the Library of Congress catalog


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Neurodegenerative diseases of the human brain constitute a major demographic problem. As life expectancy increases in the developed world, so does the incidence of these disorders, affecting an increasing percentage of the ageing population. These diseases come in various forms, causing disorders of movement and coordination, provoking cognitive deterioration and resulting in psychiatric disturbances. Many of these diseases are associated both with oxidative stress, involving the formation of reactive oxygen and nitrogen species, and with alterations in the homeostasis of a number of metal ions, notably copper, iron and zinc. The last decade has not only witnessed a growing awareness of the potential threat posed by neurodegenerative diseases as a sociological and psychological problem, but also the fact that they represent a challenge for the burgeoning applications of molecular biological approaches (genomics, proteomics) to medical problems. This, of course, leads to the concept of ‘molecular medicine’, whereby the resolution, ultimately at the molecular level, of the causes of pathological conditions, not only determines, but directs the development of therapeutic strategies. Volume 45 in the Metal Ions in Biological Systems series focuses on the devastating effects metal ions can have on proteins and related compounds.


Library of Congress subject headings for this publication:
Nervous system -- Degeneration.
Nervous system -- Diseases.
Metal ions -- Health aspects.
Neurodegenerative Diseases -- chemically induced.
Metals -- adverse effects.
Metals -- metabolism.
Prion Diseases -- chemically induced.
Protein Folding.